染色体9p21上rs10757278单核苷酸多态性与汉族人心肌梗死的相关性分析  

CORRELATION BETWEEN RS10757278 SINGLE NUCLEOTIDE POLYMORPHISM ON CHROMOSOME 9P21 AND MYOCARDIAL INFARCTION IN CHINESE HANS

作　　者：张琦[1,2] 钟光珍[3] 陈兴栋[4] 王笑峰[4] 杨新春[3] 

机构地区：[1]华北煤炭医学院附属医院心内科 [2]河北医科大学附属唐山工人医院心内科,河北省唐山市063000 [3]首都医科大学附属北京朝阳医院心脏中心 [4]复旦大学生命科学院遗传学研究所

出　　处：《中国煤炭工业医学杂志》2010年第2期173-174,共2页Chinese Journal of Coal Industry Medicine

基　　金：国家自然科学基金资助项目(30971237);唐山市科技局基金资助项目(09130202A-3-23)

摘　　要：目的研究染色体9p21上rs10757278位点单核苷酸多态性(SNP)与中国汉族人群心肌梗死患病的相关性。方法选取432例初发心肌梗死患者(MI组)及430例同期住院的外科对照患者。采用PCR-SNPStream技术对rs10757278位点进行多态性分型。并对分型结果进行统计学分析。结果在MI组,rs10757278位点的GG、AG基因型分布频率高于对照组,G等位基因分布频率也高于对照组(P<0.01)。经校正混杂因素的影响后,我们发现rs10757278位点G等位基因的单个拷贝使MI发生的风险分别提高了33%(P<0.05)。结论rs10757278是汉族人MI发生的易感位点。Objective To investigate the correlation between rs10757278 single nueleotide polymorphism （SNP） on chromosome 9021 and myocardial infarction in Chinese Hans. Methods 432 patients with myocardial infarction and 430 controls were involved. PCR- SNP Stream platform were used to genotyping SNP. Advanced analysis was performed. Results The frequency of genotype GG, AG and allele G of rs10757278 were increased in MI group, compared with control group （P〈0. 01）. After adjusted the confounding factors, we found the allele G increased the risk suffer MI by 33%. Conclusion rs10757278 is the susceptible locus to MI in Chinese Hans.

关 键 词：遗传 染色体 单核苷酸多态性 心肌梗死 

分 类 号：R394[医药卫生—医学遗传学] R473.5[医药卫生—基础医学]