血清胸苷激酶1对癌前疾病的癌变风险筛查的意义  

Serum thymidine kinase 1 and public screening for early carcinoma of precancerous diseases

作　　者：张兴华[1] 杨金荣[2] 付筱英 秦蕾[2] 刘海燕[4] 汪海霞[1] 云霞[5] 宋波[5] 张旻[5] Ellen He Sven Skog 

机构地区：[1]吉林油田总医院体检中心,松原138001 [2]吉林油田总医院检验科,松原138001 [3]吉林油田总医院劳动卫生监督所,松原138001 [4]吉林油田总医院肿瘤科,松原138001 [5]华瑞分子生物医学研究院

出　　处：《中华健康管理学杂志》2010年第1期35-38,共4页Chinese Journal of Health Management

摘　　要：目的研究血清胸苷激酶1（STK1）对癌前疾病癌变风险筛查的意义。方法吉林油田总医院对8869例不同工种人群进行常规健康体检，包括平行检测STK1。该项目检测方法是采用高灵敏度点印迹免疫增强发光检测系统来检测STK1的浓度。依据STK1检测结果将人群分类讨论。结果正常绀8355例，STK1≤2pmol／L，平均值（0．6±0．5）pmol／L；其中仅124例每项体检项目都正常占1．4％。风险组514例，STK1〉2pmol／L，平均值（3．8±2．2）pmol／L，风险率为5．8％。癌前相关疾病可能恶变风险人数为85．2％（包括胆／肾息肉样病变增生，疑肝或肺恶瘤病灶，贫血疾病，肥胖，胆／肝／肺良性肿瘤，脂肪肝和乙肝阳性并伴有肝功能异常）。发现STK1风险率升降与职业有一定相关性，第一类是长期、直接进行油田操作（钻井，运输，地质），总人数4333例，风险率7．8％；第二类是钻井前技术准备和服务（钻服，物探，钻技和测井），总人数4536例，风险率为3．9％，两类比较，第一类人群风险率有明显的升高（x^2=55．53，P〈0．05），特别是息肉样病变增生和疑恶瘤病灶者主要发现在第一类，可能与直接、长期接触油田污染物有关。结论胸苷激酶1是很有前景的血清标志物之一，它真实地反映了细胞异常增殖状况，使早期评估癌前疾病的癌变风险成为可能。Objective To investigate the role of serum thymidine kinase 1 （STK1） in public screening for early carcinoma of precancerous diseases. Methods STK1 concentrations were measured in 8869 participants by using an enhanced chemiluminesceut blot assay. Results The mean STK1 value （ n = 514） （5.8%） of the risk group （ STK1 〉 2 pmol/L） was （3.8 ± 2.2） pmol/L Only one individual with hepatoma was found. However, 85.2% of the subjects in the risk group developed precancerous diseases （gall-bladder or kidney proliferative lesions）, suspected liver or lung malignant tumor lesions, anemia disease,over-weight, benign tumor of gall-bladder, liver and lung, fatty liver and hepatitis B. Those （ n = 4333） who had long-term direct exposure to oil-related pollutants （drilling, transportations, geological prospecting） showed a higher positive rate of STK1 （7. 8% ） in comparison to those （n =4536） responsible for pre-drilling prepared technology or services （ 3.9% ） （ X^2 = 55.53, P 〈 0. 05 ）. Furthermore, those who had proliferating lesions and suspected malignant tumor lesions were mainly found in the former group （78.4%） , which might be associated with direct exposure to oil mists in the working environment. Conclusions Serum TK1 may be a reliable marker of tumor proliferating, enabling timely discovery, of early carcinoma in patients with precancerous diseases.

关 键 词：胸苷激酶 癌前状态 体格检查 

分 类 号：R730[医药卫生—肿瘤]