阴离子交换蛋白2与肿瘤  

Anion Exchanger 2 and Tumor

作　　者：王思义[1,2] 张建华[1] 

机构地区：[1]重庆医科大学妇产科,重庆400016 [2]重庆医科大学

出　　处：《中华妇幼临床医学杂志（电子版）》2010年第1期65-67,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：阴离子交换蛋白(anion exchanger,AE)2在正常人体多重组织中表达,是一种多功能嵌膜蛋白,最初在红细胞膜上被鉴定。其主要功能是转运一价阴离子,生理条件下以极快速率进行Cl-/HCO3-交换。近年来发现其在某些肿瘤中表达明显异常,可能与肿瘤的发生、发展密切相关,并可能成为肿瘤疫苗治疗的重要靶位。Anion exchanger （AE）2 expressed on many tissue of human beings. It is a versatile embedded membrane proteins, and was identified on the red blood cell membrane initially. The main function of anion exchanger 2 is to transfer anion of one price, and to exchange CI /HCOa quickly under physiological conditions. In recent years, abnormal expressions of anion exchanger 2 on some tumors were found, and it may be closely related to the occurrence and development of tumors, and may become an important target site of tumor vaccine therapy.

关 键 词：阴离子交换蛋白2 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]