阿立哌唑治疗抽动障碍的临床研究  

The effects of aripiprazole in the treatment of tic disorder.

作　　者：梁月竹[1] 周福春[1] 郑毅[1] 杨建虹[1] 刘杰[1] 王鹏[1] 戚艳杰[1] 陈旭[1] 周玉明[1] 

机构地区：[1]首都医科大学附属北京安定医院儿科,北京100088

出　　处：《精神医学杂志》2010年第1期34-35,共2页Journal of Psychiatry

摘　　要：目的探讨阿立哌唑治疗抽动障碍的疗效和安全性。方法将86例抽动障碍患者予阿立哌唑(5～25mg/d)治疗,共治疗8周。采用耶鲁抽动严重程度总体量表(YGTSS)、副反应量表(TESS)于治疗前、治疗第2、4、8周末对患者进行评估。结果患者第2、4、8周末严重程度得分与治疗前相比均有明显下降,差异有极显著性(P<0.01)。患者在治疗2、4周末副反应与治疗前相比差异有显著性(P<0.05),而第8周末与治疗前相比差异无显著性(P>0.05)。结论阿立哌唑能有效改善运动及发声抽动,副作用较轻。Objective To evaluate the efficacy and safety of aripiprazole in the treatment of tic disorder. Methods In this study,86 patients with tic disorder were treated with aripiprazole （5 - 25rag/d）for the treatment of 8 weeks. YGTSS and TESS were used to assess the efficacy and side effects before the treatment,at the end of2nd 45th and 8th week after treatment. Results The Scores of YGTSS after treatment were significantly lower than those of baseline（P 〈 0.05）. The scores of TESS at the end of 2nd and 4th week after treatment were signifieandy higher than the baseline（P 〈0.05）, while there was no significant difference between the baseline and the end of treatment （ P 〉 0.05）. Conclusion Aripiprazole is effective and safe for treating patients with tic disorder.

关 键 词：阿立哌唑 抽动障碍 儿童 少年 

分 类 号：R749.94[医药卫生—神经病学与精神病学]