氟西汀与曲唑酮对老年期抑郁症P300影响的对照研究  

Comparative study of effects of fluoxetine and trazodone on P300 in the senile depression.

作　　者：贺文[1] 唐步春[1] 

机构地区：[1]南京医科大学附属无锡精神卫生中心精神科,江苏无锡214151

出　　处：《精神医学杂志》2010年第1期39-41,共3页Journal of Psychiatry

基　　金：无锡市社会发展指导性项目课题(CSZ00843)

摘　　要：目的比较氟西汀与曲唑酮对老年期抑郁症患者认知功能的P300影响。方法将60例(年龄≥60岁)符合CCMD-3抑郁症诊断标准患者作为实验组。随机将实验组分为氟西汀治疗组(实验组1)及曲唑酮组(实验组2),对两组在治疗前、治疗8周后进行P300检测及汉密顿抑郁量表评定。与实验组性别、年龄匹配的正常老年人60例作为对照组,比较各组之间治疗前后P300及HAMD评分的差异。结果与对照组相比,治疗前实验组P2、N2、P3潜伏期及反应时间明显延长,P2、N2、P3波幅明显降低(P<0.05或P<0.01)。治疗后,实验组1 P2、N2、P3潜伏期及反应时间比治疗前明显降低,波幅明显增高(P<0.05或P<0.01);实验组2 P2、N2潜伏期及反应时间比治疗前明显降低,P2、N2、P3波幅明显增高(P<0.05或P<0.01);治疗后实验组2 P3潜伏期及反应时间比实验组1明显延长(P<0.05或P<0.01);实验组2 HAMD评分明显高于实验组1(P<0.01)。结论氟西汀与曲唑酮均有改善老年期抑郁症认知功能的作用,氟西汀优于曲唑酮。Objective To compare the effects of fluoxetine and trazodone on P300 in the senile depression. Methods Sixty patients （no less than 60 years old） met with the criteria of CCMD -3 for depression enrolled as research group and sixty healthy persons marched for sex and age were selected as normal control group. The research group was randomly divided into fluoxetine treated group （research group 1） and trazodone treated group （ research group 2）. The research groups were assessed with HAMD and measured with P300 before and at the end of 8 -week treatment. Results The latency and reactive time of P2, N2, and P3 significantly prolonged and the amplitude of p2, N2 and P3 reduced in research groups compared with normal control group（ P 〈0.05 or P 〈0.01 ）. After treatment,the latency and reactive time of P2, N2 and P3 significantly reduced and the amplitude of P2, N2 and P3 hoisted compared with the baseline in research group 1 （P 〈0.05 or P 〈0.01 ） ;the latency and reactive time of P2, N2, and P3 significantly reduced and the amplitude of P2, N2 and P3 hoisted compared with the baseline in research group 2（P 〈0.05 or P 〈0.01） ;the P3 latency and reactive time of research group 2 significantly prolonged compared with those of research group 1 （ P 〈 0.05 or P 〈0.01）. Total score of HAMD in research group 2 was significantly higher than that of research group 1 after treatment（P 〈0.01 ）. Conclusion Fluoxetine and trazodone could improve cognitive impairment in the senile depression, and the effects of fluoxetine on cognitive impairment would he better than those of trazodone.

关 键 词：老年期抑郁症 P300 认知损害 氟西汀 曲唑酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]