Hs-CRP、sCD40/CD40L和MMP-9在急性脑梗死中的作用  

The Significance of Determination of Hs-CRP,sCD40/CD40L and MMP-9 in Patients with Acute Cerebral Infarction

作　　者：程立山[1,2] 高朋杰[3] 陈晶[1,2] 宋宏杉[1,2] 付锦[4] 郭柳彩[1,2] 宋亚彬[1,2] 张立志[1,2] 冯俊强[1,2] 

机构地区：[1]黑龙江省大庆油田总医院集团龙南医院神经内科十七病区 [2]齐齐哈尔医学院第五附属医院,163453 [3]黑龙江省大庆油田总医院集团油田总医院,163001 [4]哈尔滨医科大学第二附属医院神经内科,150001

出　　处：《中华全科医学》2010年第3期321-322,共2页Chinese Journal of General Practice

摘　　要：目的探讨高敏C-反应蛋白(High sensitivity C-reactive protein,Hs-CRP)、可溶性细胞表面分化抗原40及其配体(sCD40/CD40L)和基质金属蛋白酶-9(Matrix metallo proteinases-9,MMP-9)在脑梗死后斑块破裂局部和外周血含量的变化,破裂斑块和未破裂斑块炎性因子的变化是否存在差异,并与常规动脉造影组进行对比。方法急性脑梗塞动脉溶栓组和常规血管造影组分别取局部动脉血和外周静脉血进行上述炎症介质测定。结果动脉溶栓组炎症介质显著高于常规血管造影组,但动静脉相比较差异无统计学意义。结论Hs-CRP、sCD40/CD40L和MMP-9在急性脑梗死时明显高于正常,但局部血与静脉血无明显差异。Objective To investigate the changes of the peripheral blood high sensitivity C-reactive protein （Hs-CRP）, soluble cell surface differentiation antigen 40 ligand（sCD40/CD40L） and matrix metal proteinase-9 （MMP-9）in patients with the cerebral infarction before and after the mottling partially burst. Contrast was carried out with the conventional artery radiography group. Methods Determination of the above inflammation medium in the partial artery blood and the circumference venous blood was carried out in both the acute cerebral infarction group（ artery hitch was dissolved） and the convention angiography group. Resuits The levels of inflammation medium in acute cerebral infarction group were significantly higher than those of the convention angiography group;there was no significant difference in inflammation medium between the artery blood and the circumference venous blood. Conclusion Hs-CRP, SCD40/CD40L and MMP-9 were valuable in the diagnosis, therapy and prognosis of acute cerebral infarction.

关 键 词：脑梗死 高敏C-反应蛋白 可溶性细胞表面分化抗原40及其配体 基质金属蛋白酶 动脉溶栓 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R543.5[医药卫生—临床医学]