氟西汀治疗持续的躯体形式疼痛障碍的随机双盲安慰剂对照研究  

A placebo-controlled,double-blind and randomized trial of fluoxetine in the treatment of persistent somatoform pain disorder

作　　者：骆艳丽[1] 张明园[2] 吴文源[1] 李春波[2] 陆峥[1] 姚军[1] 李清伟[1] 

机构地区：[1]同济大学附属同济医院,上海200065 [2]上海交通大学医学院精神卫生中心

出　　处：《临床精神医学杂志》2010年第1期1-3,共3页Journal of Clinical Psychiatry

基　　金：上海市科学技术委员会资助项目(014119073)

摘　　要：目的:验证氟西汀治疗持续的躯体形式疼痛障碍的镇痛疗效。方法:80例持续的躯体形式疼痛障碍患者,随机分为氟西汀组和安慰剂组,观察8周,采用医学结局研究用疼痛量表(MOSPM)和汉密尔顿抑郁量表17项(HAMD17)评估氟西汀镇痛疗效。结果:与安慰剂组相比,治疗8周后氟西汀组MOSPM总分降低显著低于安慰剂组。治疗第2周末氟西汀组与安慰剂组间有统计学差异。氟西汀组患者中,伴有抑郁情绪的患者镇痛疗效较好。结论:氟西汀治疗持续的躯体形式疼痛障碍有效。Objective： To assess the analgesic efficacy of fluoxetine in the treatment of persistent somatoform pain disorder. Method：80 patients meeting the persistent somatoform pain disorder were randomly assigned to receive fluoxetine or placebo in an 8-week, double-blind study. The medical outcome study pain measures（MOSPM） and Hamilton depression scale （HAMD17）were used to assess the analgesic efficacy of fluoxetine. Results：Compared with placebo-treated subjects, subjects receiving fluoxetine had a greater reduction in MOSPM total score than placebo-treated patients. There was significant difference of MOSPM total score at week 2 between the fluoxetine and placebo group. In fluoxetine group, patients with depression have better analgesic effect than non-depressed patients. Conclusion： Fluoxetine has a better analgesic efficacy than placebo in treating persistent somatoform pain disorder.

关 键 词：氟西汀 持续的躯体形式疼痛障碍 

分 类 号：R749.053[医药卫生—神经病学与精神病学]