丁苯肽对急性脑梗死患者血清TNFα-、CRP和神经功能缺损程度评分的影响  

Effects of Dl-3n-Butylphthalide on Serum TNF-α,CRP and Neural Functional Impairment Scoring in Acute Cerebral Infarction Patients

作　　者：刘小阳[1] 杜万红[1] 杨浩军[1] 张勇[1] 

机构地区：[1]解放军第163医院老干科,湖南长沙410003

出　　处：《临床军医杂志》2010年第1期90-92,共3页Clinical Journal of Medical Officers

摘　　要：目的观察丁苯肽对急性脑梗死的早期治疗作用。方法80例急性脑梗死患者随机分为丁苯肽治疗组及常规对照组各40例,分别采集患者治疗前和治疗后第14天外周血标本,测定血清肿瘤坏死因子(TNFα-)和C-反应蛋白(CRP)水平,同时对患者治疗前及治疗后第7、14天进行神经功能缺损程度评分。结果治疗组和对照组第14天血清TNFα-、CRP水平较治疗前降低(P<0.01),且治疗组较对照组显著降低(P<0.01);第7、14天神经功能缺损程度评分治疗组较对照组有明显改善(P<0.01)。结论丁苯肽对急性脑梗死的早期有显著治疗作用。Objective To investigate the early curative effects of dl-3n-butylphthalide in acute cerebral infarction patients. Methods A total of 80 acute cerebral infarction patients were randomly divided into dl-3n-butylphthalide treatment group （ n = 40） and control group （n = 40）. The levels of tumor necrosis factor-a（TNF-cx） and C-reactive protein（CRP） in the peripheral blood samples were detected before treatment and 14 days after treatment, respectively. The defect scoring of nervous function was evaluated before treatment and 7-and 14 days after treatment, respectively. Results Serum TNFdl-3n-butyphthalide ; cerebral infarction ; acute ; tumor necrosis factor-α ; C-reactive protein and CRP levels were lower after 14 days＇ treatment than before （P 〈 0.01 ） , and there wasa significant difference between the treatment group and the control group（ P 〈0.01 ）. The defect scoring of nervous function was more obviously improved in the treatment group than in the control group after 7-and 14 days＇ treatment. Conclusion D1-3n-butylphthalide has notable therapeutic effect on early acute cerebral infarction.

关 键 词：丁苯肽 脑梗死 急性 肿瘤坏死因子-α C-反应蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]