颅内肿瘤患者记忆损害的评价及术后随访  

Preoperative and postoperative assessment of memory function for intracranial tumor patients

作　　者：沈超[1] 谢嵘[1] 鲍伟民[1] 郭起浩[1] 余果[1] 曹晓运[1] 杨伯捷[1] 毛颖[1] 

机构地区：[1]复旦大学附属华山医院神经外科,上海200040

出　　处：《中华医学杂志》2010年第5期301-304,共4页National Medical Journal of China

摘　　要：目的评价各种颅内肿瘤及肿瘤切除术对患者记忆功能的影响。方法运用4种记忆量表对58例颅内肿瘤患者进行记忆功能的评价，包括即刻记忆、延迟记忆、线索记忆、长时记忆，其中35例进行术后随访。另选18名正常人作为正常对照组。结果凸面脑外肿瘤患者存在延迟记忆和长时记忆损害（P〈0．05）。而脑内肿瘤患者术前即刻记忆，延迟记忆，长时记忆均存在损害，尤其是长时记忆损害（P〈0．01），较为严重；优势半球肿瘤患者各型记忆损害均较副侧半球肿瘤患者严重；脑内肿瘤患者术后较术前长时记忆能力下降（P〈0．01）；而鞍区肿瘤患者术前不存在记忆损害，经鼻蝶鞍区肿瘤切除术不影响患者记忆功能。结论颅内肿瘤能够引起记忆损害。不同部位不同性质颅内肿瘤引起的记忆损害存在差异。脑内肿瘤要比脑外肿瘤严重，优势半球要比副侧半球严重，手术肿瘤切除术使长时记忆功能下降。Objective To analyze the effects of intracranial tumors and tumor resection on patients＇ memory functions. Methods Four different memory scales were employed to evaluate 58 intracranial tumor patients＇ memory functions including short-term memory, delayed memory, clue memory and long-term memory. Thirty-five patients received postoperative follow-ups. There were also 18 healthy controls. Results The extra-cerebral tumor patients presented with delayed memory and long-term memory disorders while intra-cerebral tumor patients suffered from short-term, delayed and severe long-term memory disorders. Patients with dominant hemispheric tumors had more serious memory disorders in all types. Scores obtained after surgery showed an aggravated long-term memory disorder. Sellar region tumors and transsphenoidal tumor resection had no effects upon memory functions. Conclusion Intracranial tumors cause memory disorders. Tumors with different locations and characters have different memory impairments. Intra-cerebral tumors result in more severe memory impairment than extra-cerebral tumors. And dominant hemispheric tumors are worse than non-dominant hemispheric tumors. Tumor resection decreases long-term memory functions.

关 键 词：记忆 中枢神经系统肿瘤 神经心理学 

分 类 号：R739.4[医药卫生—肿瘤]