人类牙周膜组织中MMP-2及TIMP-2的比较研究  

Comparison of MMP-2 and TIMP-2 in Diseased and Healthy Periodontal Ligament

作　　者：韩建国[1] 王丽[1] 韩斐斐[2] 丁志江[1] 

机构地区：[1]徐州医学院口腔医学系,江苏徐州221004 [2]徐州医学院临床学院

出　　处：《口腔医学研究》2010年第1期50-51,55,共3页Journal of Oral Science Research

摘　　要：目的:比较基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶抑制因子-2(TIMP-2)在健康牙周组织(PDL)和病变牙周组织中的表达。方法:收集20例健康PDL和病变PDL组织样本,用ELISA法检测其中的MMP-2,TIMP-2水平。结果:牙周炎患者组PDL中的MMP-2的水平明显高于健康组(P<0.01),牙周炎患者组PDL中的TIMP-2的水平高于健康组(P<0.05),但MMP-2/TIMP-2明显增高。结论:研究提示MMP-2/TIMP-2失调与牙周组织破坏有关。Objective： To compare the expression of MMP-- 2 and TIMP--2 in diseased and healthy periodontal ligament. Methods： 20 diseased and 20 healthy periodontal ligament samples were collected. Assays for MMP--2 and TIMP--2 in PDL were performed by ELISA. Results： Levels of MMP--2 were higher in patients than those in the controls （P〈0. 01）. Levels of TIMP--2 were lower in patients than those in the controls （P〈0.01）. Conclusion： The levels of MMP--2 are higher in the periodontium of subjects with periodontitis and might contribute to periodontal destruction.

关 键 词：基质金属蛋白酶-2 金属蛋白酶抑制剂-2 牙周组织 

分 类 号：R78[医药卫生—口腔医学]