对烷氧基取代MeO-BIPHEP型手性双膦钌配合物催化β-酮酸酯不对称加氢反应  

Asymmetric Hydrogenation of β-Ketoesters Catalyzed by Ru Complex with Para-alkoxy Substituted MeO-BIPHEP Type Diphosphine Ligands

作　　者：彭宗海[1] 马梦林[1,2] 付海燕[1] 陈华[1] 李贤钧[1] 

机构地区：[1]四川大学化学学院有机金属络合催化研究所,教育部绿色化学与技术重点实验室,四川成都610064 [2]西华大学化学系,四川成都611930

出　　处：《催化学报》2010年第2期191-194,共4页

摘　　要：报道了对烷氧基取代的MeO-BIPHEP型手性双膦配体钌配合物催化的β-酮酸酯不对称加氢反应,考察了反应温度、压力、底物/催化剂摩尔比和溶剂对反应的影响.结果表明,在乙醇中该配合物催化3-丁酮酸乙酯加氢反应的对映选择性达98.0%,且对含不同取代基的β-酮酸酯均表现出较高的活性和对映选择性.A series of optically active MeO-BIPHEP type ligands, （R）-6,6＇-dimethoxy-2,2＇-bis（di-p-alkoxyphenyl-phosphine）-1,1＇-biphenyl, were synthesized, and the ruthenium complex with these ligands, [Ru（diphosphine）（C6H6）Cl]Cl, was applied for the asymmetric hydrogenation offl-ketoesters. Influence of temperature, pressure, substrate/catalyst molar ratio, and solvents was tested. The results showed that the 98.0% of ee value was achieved for the hydrogenation of ethyl acetoacetate in EtOH. [Ru（diphosphine）（C6H6）Cl]Cl showed high catalytic activity and enantioselectivity for the asymmetric hydrogenation of various β-ketoesters.

关 键 词：Β-酮酸酯 不对称加氢 联苯类配体 钌配合物 

分 类 号：O643.32[理学—物理化学]