癌性贫血对恶性肿瘤患者生活质量及生存期的影响  

Influence of malignant tumor anemia on the malignancy patients' quality of life and survival

作　　者：高艳[1] 许崇安[1] 刘殊[1] 李琳[1] 冯丹[1] 张学梅[1] 

机构地区：[1]中国医科大学附属第四医院肿瘤内科,辽宁沈阳110032

出　　处：《中华肿瘤防治杂志》2009年第24期1957-1960,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨癌性贫血对恶性肿瘤患者生活质量(QOL)及生存期的影响。方法:对120例实体肿瘤患者进行分析,统计癌性贫血的发生率,分析其与肿瘤类型、肿瘤分期、患者年龄及性别的关系。结果:120例恶性肿瘤患者中癌性贫血发生率为66.7%,不同病种之间的癌性贫血发生率差异有统计学意义(P<0.05),以消化系统肿瘤癌性贫血的发生率最高(80.4%)。癌性贫血的发生率随肿瘤分期的升高而升高,而与性别及年龄无关。癌性贫血不仅影响患者的QOL,并且影响患者的生存期。随贫血的加重,QOL下降,生存率减低,生存期缩短。多因素分析显示,癌性贫血是影响肿瘤患者生存的显著预后因素。结论:癌性贫血不仅降低肿瘤患者的QOL,而且还降低生存率,缩短生存期,是影响肿瘤患者生存的不良预后因素之一。OBJECTIVE：To study the influence of malignant tumor anemia （MTA） on the malignancy patients＇ quality of life （QOL） and survival. METHODS：A total of 120 solid tumor patients were included in this study,and the incidence of MTA was calculated. The relationship between the hemoglobin level and the clinical information including tumor grade,tumor kind,sex and age was analyzed. RESULTS：The incidence of MTA was 66.7% in the overall 120 malignancy patients. The difference of the incidence of MTA among various malignancies was statistically significant（P0.05） and the highest proportion （80.4%） was observed in the gastrointestinal malignancies. The incidence of MTA got higher with the elevation of tumor grade,but it was not related to sex and age. MTA significantly influenced the malignancy patients＇ QOL and survival. With the decline of the hemoglobin level,not only the malignancy patients＇ QOL got worse,but also the survival rate got lower,and the survival time got shorter. The multivariate analysis indicated that MTA was a significant influence factor for the malignancy patients＇ survival. CONCLUSIONS：In addition to the negative effect on the malignancy patients＇ QOL,MTA is associated with the decreased survival rate and the reduced survival time. MTA is one of the adverse prognostic factors for survival in malignancy patients.

关 键 词：肿瘤/并发症 贫血 生活质量 生存率 

分 类 号：R73-31[医药卫生—肿瘤]