聚肌胞兔滤过术后结膜下注射对成纤维细胞的影响  

The effects of Poly I:C on the rabbit conjunctival fibroblast after trabeculectomy

作　　者：刘政[1] 王新美[2] 李凯军[1] 王彬 刘援[4] 李波[1] 

机构地区：[1]淄博市中心医院眼科,山东淄博255036 [2]淄博市中心医院病理科,山东淄博255036 [3]张店区人民医院内科,山东淄博255000 [4]淄博康明眼科医院,山东淄博255000

出　　处：《眼外伤职业眼病杂志》2010年第2期92-94,共3页Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries

摘　　要：目的研究聚肌胞注射液对兔滤过术后滤过道的组织病理学变化及毒性。方法对10只新西兰兔双眼小梁切除术，于术中、术后一组（每兔1眼）球结膜下注射聚肌胞，对照组（每兔另1眼）球结膜下注射生理盐水。术后3、5、10、15d行术眼眼压和裂隙灯显微镜检查。术后5、7、10、15d行术眼病理切片光镜观察。结果对照组的滤过泡于术后7d失败，聚肌胞组的滤过泡于术后14d失败，术后7～10d聚肌胞组巩膜瘘道阻塞率是40％，对照组巩膜瘘道全部阻塞。结论对兔眼滤过术中、术后应用聚肌胞可以抑制成纤维细胞增生，暂时提高兔眼滤过术的成功率，无副作用。Objective To investigate the effects of polyinosinic-polycytidylic （Poly I ：C） on the rabbit conjfinctival fibroblast after trabeculeetomy. Methods 10 New Zealand rabbits （20 eyes） were divided into Poly I： C group and normal saline groups. All rabbits＇ eyes received traubeculectomy. The Poly I：C group eyes received Poly I：C sub-conjunetival injection after trabeeulectomy and the normal saline group eyes received normal saline subconjunctival injection after trabeculectomy. All eyes received IOP measurement and slit lamp microscopy examination 3,5,10,15 days after surgery. Pathological section of all eyes underwent histological examination 5, 7, 10, 15 days after surgery. Results All bubbles in normal saline group eyes were failure 7 days after operation and that in Poly I：C group eyes were failure 14 days after operation. The ratio of blockage filtration path in Poly I： C group eyes was 40% after 7-14 days and that in the normal saline group was 100%. Conclusion Application of Poly I：C after trabeculectomy in rabbit eyes can inhibited fibroblast proliferation and improved achievement ratio of trabeculectomy.

关 键 词：聚肌胞 青光眼 小梁切除术 

分 类 号：R779.6[医药卫生—眼科]