电刺激小脑顶核在脑缺血大鼠中的内源性神经保护机制  

Review on the Endogenous Neuroprotection Mechanisms of the Cerebellar Fastigial Nucleus Stimulation in Rats with Ischemic

作　　者：汪晓玲[1] 刘竞丽[1] 

机构地区：[1]广西医科大学第一附属医院神经内科,南宁530021

出　　处：《医学综述》2010年第4期481-484,共4页Medical Recapitulate

基　　金：国家自然科学基金(30860291)

摘　　要：成熟神经元不可再生,完全缺血5 min即可导致神经元不可逆性死亡。电刺激小脑顶核具有脑保护作用,能提高脑缺血大鼠对缺血、缺氧的耐受性,但其具体机制不明。主要从抑制炎性反应、降低缺血半暗带的电兴奋性、抑制神经元凋亡、促进结构重建、功能恢复、促进内源性神经干细胞生长等方面就电刺激小脑顶核的内源性神经保护机制进行阐述,尤其关注到它促进内源性神经干细胞生长对缺血性脑血管病的意义。Mature neurons can′t regenerate,they will die without blood supply for 5 minutes.Electrical stimulation of the cerebellar fastigial nucleus can preserve the brain,and elevate the toleration to ischemia and hypoxia of cerebral ischemia rats.But the mechanisms was unknown.Endogenous neuroprotection mechanisms of fastigial nucleus was discussed from following aspect such as inhibiting inflammation,decreasing electrical excitability in the ischemia semidarkness,inhibiting neuron apoptosis,promoting structures and functions recovery,promoting endogenous nerval stem cell growing,expecially the effect of promoting endogenous nerval stem cell growing for ischemic cerebrovascular diseases.

关 键 词：小脑顶核 电刺激 内源性神经保护 

分 类 号：R743[医药卫生—神经病学与精神病学]