N-[2-(1H-吲哚-3)乙基]-2-乙酰噻唑-4-甲酰胺及其类似物的合成  

Synthesis of N-[2-(1H-Indol-3-yl)ethyl]-2-acetylthiazole-4-caboxamide and Its Analogues

作　　者：李多[1] 杨海申[1] 谢龙观[1] 徐效华[1] 

机构地区：[1]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2010年第2期238-243,共6页Chinese Journal of Organic Chemistry

摘　　要：N-[2-(1H-吲哚-3)乙基]-2-乙酰噻唑-4-甲酰胺是最近从海洋细菌中分离得到的一种新型的天然杀藻剂,以D-丙氨酸为原料合成了该化合物,并用类似的方法首次合成了它的类似物2,3和4.其关键步骤为通过将取代的4-噻唑甲酸制成混酐与色胺连接的偶联反应.各中间体都通过1HNMR和13CNMR得到证实.最终产品通过1HNMR,13CNMR和HRMS证实,与文献所报道相一致.The synthesis of N-（2-（1H-indol-3-yl）ethyl）-2-acetylthiazole-4-carboxamide （1）, which is a new algaecide from the marine bacterium, was achieved effectively from D-alanine. Its analogues 2, 3 and 4 were firstly synthesized using the similar approach. The key step was a coupling reaction via the mixed anhydride. All structures were confirmed by ^1H NMR and ^13C NMR spectra. The final compounds were confirmed by ^1H NMR, ^13C NMR and HRMS techniques, and the results are consistent with the reported natural products.

关 键 词：天然化合物 天然杀藻剂 丙氨酸 噻唑 混酐 色胺 

分 类 号：O626[理学—有机化学]