一锅煮法合成苯基苄基酮缩氨基硫脲  

One-Pot Synthesis of Phenyl-benzylketone Thiosemicarbazone

作　　者：庄肃凯 贺云[1] 张创军 高润莉 张尊听[1] 

机构地区：[1]陕西师范大学药用资源与天然药物化学教育部重点实验室西北濒危药材资源开发国家工程实验室陕西师范大学化学与材料科学学院,西安710062

出　　处：《有机化学》2010年第2期299-302,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20772076);西安市科技计划(No.FY07075)资助项目

摘　　要：以天然产物异黄酮与氨基硫脲为原料,在碱性条件下乙醇为溶剂,合成了10种苯基苄基酮缩氨基硫脲化合物.此方法操作简便、条件温和、且产率较高,是合成苯基苄基缩氨基硫脲的一种简便实用的方法.采用IR,1HNMR,13C NMR和元素分析对这10种化合物结构进行了表征.Using natural product isoflavones and thiosemicarbazide as starting materials, ten phenyl-benzylketone thiosemicarbazone derivatives were synthesized from the solution of alkali alcohol. This method is a convenient and efficient way to the synthesis of thiosemicarbazones based on isofiavones and thiosemicarbazide, which has several advantages such as simple operation, short reaction time, mild conditions and high yields. The structures of the ten thiosemicarbazones were identified by IR, NMR spectra and elemental analysis.

关 键 词：异黄酮 氨基硫脲 缩氨基硫脲 一锅合成法 

分 类 号：TQ247[化学工程—有机化工]