胃肠道间质瘤20例临床病理分析  

Gastrointestinal Stromal Tumor Clinicopathological Analysis of 20 Cases

作　　者：李莉娜[1] 杨苏敏[1] 

机构地区：[1]长治医学院病理学教研室,046000

出　　处：《长治医学院学报》2010年第1期16-18,共3页Journal of Changzhi Medical College

摘　　要：目的:探讨胃肠道间质瘤(GIST)的临床病理特点。方法:分析20例胃肠道间质瘤的临床病理病例资料并应用CD117、CD34、SMA和S-100进行免疫组织化学标记。结果:20例GIST中男女发病例数相等,平均年龄59岁。肿瘤常见于胃,多呈结节状,大小不等,瘤体边界清楚,部分切面可见出血、坏死、囊性变。组织学类型为梭形细胞型。免疫组化示CD117阳性占95%、CD34阳性80%,SMA、S-100均为局灶状阳性,阳性率分别为40%和15%。20例GIST极低度风险3例、低度风险7例、中度风险2例、高度风险8例。结论:胃肠道间质瘤主要见于中老年人,男女发病率无明显差异,胃发病率最高,CD117、CD34联合应用可提高诊断率,GIST可以向肌源性分化或向神经分化。Ohjective ：To investigate the clinicopathological featnres of GIST. Methods ： To aualyze the clinical and pathological information of twenty cases of GIST and apply CDl17, CD34,SMA and S - 100 for immunohistochemical staining. Results：The cases of male and female were equal and the average age was 59 years old.The tumors were commonly found in stomach ,usually appeared nodular with different sizes, clear edge, and hemorrhage, necrosis, and cystic change can be seen in some cases. Histological types of the 20 GIST were spindle cell. Immunohistochemical staining showed 95 % positive reaction of CD117, 80% positive reaction of CD34,and SMA,S - 100 were the focal - like positive,the positive rates were 40% and 15%. 20 cases of GIST have an extremely low degree of risk in 3 cases,low risk, in 7,moderate risk in 2 and high risk in 8. Conclusion：GIST was mainly seen in the elderly. There was no significant difference belween males and females, and usually occlnTed in stomach. CD117, CD34 incombination can improve diagnosis. GIST can myogenic differentiation or to the neural differentiation.

关 键 词：胃肠道间质肿瘤 临床病理 免疫组化 

分 类 号：R361[医药卫生—病理学]