检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:陈宇萍[1]
机构地区:[1]海军总医院基础医学研究中心,北京100048
出 处:《生命科学》2010年第1期69-73,共5页Chinese Bulletin of Life Sciences
摘 要:HER-2/neu癌基因在许多肿瘤,如乳腺癌、卵巢癌、非小细胞肺癌等肿瘤中高表达,在肿瘤的发生与发展中起重要作用,与肿瘤的转化、转移、复发、预后差、患者生存期缩短有关。HER-2/neu在乳腺癌过度表达率约为20%~30%,编码蛋白P185HER2属生长因子受体家族,抗P185HER2单克隆抗体(Herceptin)作为靶向药物已临床应用治疗HER2/neu高表达乳腺癌。HER-2/neu oncogene is overexpressed in many kinds of tumors like breast cancer, ovarian cancer, nonsmall-cell lung cancer(NSCLC). Overexpression of HER-2/neu has significant effect on tumor occuring and development, it is associated with tumor inversion, metastasis, recuring, poorer prognosis and patient's shortening of life. HER-2/neu is overexpressed in approximately 20%-30% patients with breast cancer. The coding protein P185HER2 of HER-2/neu is a member of the human epidermal growth factor receptor family. Monoclonal antibody of P185HER2(Herceptin) is clinically used as a targeted drug for HER-2/neu overexpressed breast cancer.
关 键 词:HER-2/NEU基因 P185HER2 靶向治疗
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.229