HIV-1 Tat蛋白神经毒作用的研究进展  

Progress in study on neurotoxicity of HIV-1 Tat

作　　者：滕竞飞[1] 高霄飞[2] 

机构地区：[1]第二军医大学临床医学八年制,上海200433 [2]第二军医大学神经生物学教研室,上海200433

出　　处：《生命科学》2010年第1期84-88,共5页Chinese Bulletin of Life Sciences

摘　　要：HIV-1感染者常并发神经系统损伤,患者主要表现为运动功能障碍,认知和行为受损等。研究表明,HIV-1多种蛋白参与上述病理过程,其中Tat蛋白发挥了极为重要的作用。外周Tat蛋白可透过血脑屏障进入脑组织,与脑内感染细胞分泌或释放至胞外的Tat共同作用于NMDAR、mGluR1、多巴胺转运蛋白等,损伤神经系统。该文主要对Tat蛋白的神经毒作用作一综述。Infection with HIV-1 is always associated with dysfunctions of central nervous system（CNS）, the patients are characterized by motor dysfunctions, impaired cognitions and behaviors. Relative researches indicated that, various HIV-1 proteins are responsible for the pathogenesis, among which, Tat is of vital importance. Peripheral Tat, which can cross the blood-brain barrier and infiltrate the brain tissues, as well as that secreted or released from HIV-1-infected cells, can interact with NMDAR, mGluR1, dopamine transporter, etc. and thus cause damages to central nervous system （CNS）. The neurotoxicity effects of HIV- 1 Tat were reviewed here.

关 键 词：HIV-1 TAT 血脑屏障 神经毒 

分 类 号：Q291[生物学—细胞生物学] R742[医药卫生—神经病学与精神病学]