Nd:YAG激光联合丝裂霉素及典必殊眼膏治疗泪道阻塞  

Clinical exploration of Nd:YAG laser combined with mitomy C and TobraDex Ophthalmic ointment in the treatment of lacrimal passage obstruction

作　　者：张磊[1] 罗丰年[1] 孙叙清[1] 杜刚[1] 陈静[1] 

机构地区：[1]解放军161医院五官科,武汉430010

出　　处：《临床眼科杂志》2010年第1期74-76,共3页Journal of Clinical Ophthalmology

摘　　要：目的观察Nd:YAG泪道激光机联合丝裂霉素(MCC)及典必殊眼膏治疗泪道阻塞的效果。方法将399例(418只眼)泪道阻塞患者随机分为3组,MCC+典必殊眼膏组136只眼,采用常规激光泪道成形术后将0.2 ml MMC注入泪道5 min后,应用典必殊眼膏填充泪道;典必殊眼膏组152只眼,常规激光泪道成形术后典必殊眼膏填充泪道;对照组56只眼,术毕注入生理盐水。观察3组患者术后的疗效,并对其进行统计学处理。结果随访6个月,MCC+典必殊眼膏组与典必殊眼膏组术后早期(术后1个月)有效率分别是97.1%和86.8%,二者比较无差异,无统计学意义(P>0.05),而远高于对照组生理盐水组有效率57.1%(P<0.05);后期疗效(术后3～6个月),MCC+典必殊眼膏组有效率为85.3%,典必殊眼膏组为65.8%,经统计学统计,P<0.05,MCC+典必殊眼膏组显著优于典必殊眼青组。结论使用MCC+典必殊眼膏可提高泪道阻塞的远期治愈率。Objective To evaluate the therapeutic efficacy of intrapperative mitoomycin C （ MCC ） and TobraDex ophthalmic ointment（TDO} in transcanalicular Nd： YAG laserassisted daeryocystoplasty（ LDCL）. Methods Four hundred eighteen eyes with obstruction of lacrimal passage were randomly divided into MMC ＋ TDO group ,TDO group and control group, In MCC ＋ TDO group 136 eyes firstly applied 0.2 ml MMC for 5 rain , then filled up TobraDex ophthalmic ointment. In TDO group 152 eyes filled up on TobraDex ophthalmic ointment without MMC. In control group 56 eyes only filled up on 0.9% Nad. Results All patients were followed up for 6 months. In 1 months It was found that the healing rates of two drug group were 97.1%, 86.8%, After stastistics rest ,there was not difference between two groups （ P 〉0.05 ）, respectively significantly higher than that of the control group （ 57.1 ） （ P 〈 0.05 ）. In 3 - 6 months It was found that the healing rates of MMC ＋TDO group were 85.3%, the healing rates of TDO group were 65.8%, After stastistics rest ,there was a great significant difference between two groups（ P 〈0.05）, MCC combined with TDO respectively significantly higher than that of the TDO group. Conclusion MCC combined with TDO or TDO is effective on patients treated with LDCL in longer term.

关 键 词：泪道阻塞 激光 丝裂霉素C 典必殊眼膏 

分 类 号：R777.2[医药卫生—眼科]