凋亡在肺缺血再灌注损伤中作用机制的研究进展  

Role of cell apoptosis in pulmonary ischemia-reperfusion injury

作　　者：冯冬杰[1] 许林[1] 

机构地区：[1]南京医科大学附属江苏省肿瘤医院胸外科,南京医学硕士研究生210009

出　　处：《医学研究生学报》2010年第2期214-217,共4页Journal of Medical Postgraduates

基　　金：江苏省社会发展重大项目基金(BS2006005)

摘　　要：随着肺移植、体外循环以及肺外科中单侧肺循环阻断技术的广泛应用,肺缺血再灌注损伤(LIRI)对于术后肺功能的影响日益受到关注。术中因肺缺血而引起的肺组织坏死一直被认为是影响肺功能的最重要原因,然而近年的研究表明细胞凋亡尤其是肺泡Ⅱ型上皮细胞(ATⅡ)的凋亡也起重要作用,凋亡在肺缺血再灌注损伤中的机制成为研究热点。文中对该领域的最新进展进行综述。In recent years, with the wide application of lung transplantation, cardiopulmonary bypass and the pulmonary vessel blocking technique, more and more attention has been aroused to the effect of lung ischemia-reperfusion injury （LIRI） on postoperative pulmonary function. For years, LIRI - induced pulmonary tissue necrosis was thought to be the major cause of lung injury. However, recent studies suggest that cell apoptosis, particularly that of alveolar type Ⅱ cells, plays a vital role as well. Therefore, an increasing number of investigators have focused on cell apoptosis in the mechanism of LIRI.

关 键 词：凋亡 肺缺血再灌注损伤 肺泡Ⅱ型上皮细胞 

分 类 号：R364.1[医药卫生—病理学]