CD117和CD34在胃肠道间质瘤中的表达及其临床意义  

The expressions and their clinical signifiicance of CD117 and CD34 in gastrointestinal stromal tumors（GISTs）

作　　者：温建成 王延红 黄小萍[2] 苏少雪[2] 刘俊斌[2] 郑淑妍[2] 

机构地区：[1]广东省深圳市横岗人民医院,广东深圳518115 [2]广东省潮州市中心医院病理科,广东潮州521000

出　　处：《现代肿瘤医学》2010年第3期509-510,共2页Journal of Modern Oncology

摘　　要：目的：探讨CD117和CD34在胃肠道间质瘤（GISTs）中的表达及其临床意义。方法：免疫组织化学法检测CD117和CD34在46例GISTs患者手术切除肿瘤组织和24例真性平滑肌瘤（对照组）中的表达，并观察GISTs的病理学特征。结果：GISTs患者手术切除肿瘤组织在光镜下主要由数量不等的梭形和（或）上皮样细胞组成，梭形细胞排列成束状、编织状或旋涡状，上皮样细胞多呈弥漫片状、束状或巢状排列，两种细胞可按不同比例混合性或单一性组成肿瘤的实体。CISTs组织中CD117、CD34阳性表达率分别为100．0％、84．8％，对照组真性平滑肌瘤组织中CD117和CD34均：无表达。GISTs主要发生在胃（52，2％，24／46）和小肠（26．1％，12／46）。结论：CD117和CD34是诊断GISTs比较特异性的抗体，具有非常重要的诊断价值。Objective：To study the expressiorLs and their clinical significance of CD117 and CD34 in gastrointestinal stromal tumors （GISTs）. Methods：Total of 46 cases of GISTs were studied by routine pathologic examination and immunohistochemical stains for CD117 and CD34. Results：All 46 cases of GISTs consisted of two basic cell types： spindle and epithelioid cells. The positive rates of CDll7 and CD34 were 100% and 84.8% respectively in GISTs. 52.2% cases of GISTs originated in stomach,26.1% cases in small intestine. Conclusion：Expressions of CD117 and CD34 are the special antibodies for GISTs,and the high positive expression of CDl17 and CD34 plays a very important role in the diagnosis of GISTs.

关 键 词：胃肠道间质瘤 免疫组织化学 CD117 CD34 

分 类 号：R730.3[医药卫生—肿瘤]