周剂量DCF方案治疗晚期胃癌临床观察  

Clinical observation of weekly dose of DCF in the treatment of advanced gastric cancer

作　　者：赵亚宁[1] 耿熠[1] 刘晓凤[1] 

机构地区：[1]宝鸡市中心医院肿瘤内科,陕西宝鸡721008

出　　处：《现代肿瘤医学》2010年第3期526-527,共2页Journal of Modern Oncology

摘　　要：目的:观察周剂量多西他赛联合顺铂、氟尿嘧啶(DCF)方案治疗晚期胃癌近期临床疗效及不良反应。方法:对21例晚期胃癌患者,采用多西他赛60mg/m2分两次静脉滴入,d1、d8;顺铂25mg/m2静脉滴入,d1-3;亚叶酸钙150-200mg/m2静滴d1-5,静滴2小时后,氟尿嘧啶750mg/m2持续静滴6小时以上或口服卡培他滨1000mg/m2,d1-14。21d为1个周期,至少2个周期后评价疗效。结果:全组21例可评价疗效,结果PR5例,SD9例,总有效率66.7%。患者KPS及QOL评分改善。不良反应主要为骨髓抑制、消化道反应和脱发,III/IV度骨髓抑制28.8%,消化道反应多为III度,均为可逆性。结论:周剂量多西他赛联合顺铂、氟尿嘧啶治疗晚期胃癌近期疗效好,不良反应轻,患者耐受性好。Objective：To investigate the efficacy and adverse reaction of weekly docetaxel combined with cisplatin and 5 - FU for advanced gastric cancer. Methods： Twenty one patients with metastatic or unresectable gastric carcinoma who had measurable lesions were treated with the following regimen, docetaxel 60 mg/m2 by i. v on dl.s ,cisplatin 25mg/m2 · d on d1-3, calcium folinate 150 - 200 mg/m2 ·d , and 6 hours later 5 - FU 750 mg/m2 · d on dI -s or capecitabine 1000mg/m2 for 14 days . The chemotheropy were repeated every 3 weeks, and all patients received at least 2 cycles. Results：The overall response rate PR ＋ SD was 66.7%. KPS and QOL of patients were improving. The major toxicity were myelo -suppression（ Ill/IV,28.8% ）, nausea/vomiting and trichomadesis, most were slight and reversible. Condusoins：Weekly DCF for advanced gastric cancer is effective and tolerable.

关 键 词：胃癌 多西他赛 顺铂 氟尿嘧啶 周剂量 不良反应 

分 类 号：R735.2[医药卫生—肿瘤]