伴有复杂核型的急性早幼粒细胞白血病的临床及实验研究  

Clinical and laboratory research of two acute promyelocytic leukemia patients with complex karyotype

作　　者：马力[1] 李建勇[2,3] 潘金兰[4] 

机构地区：[1]大连市友谊医院肿瘤血液科,辽宁大连116001 [2]南京医科大学附属第一医院 [3]江苏省人民医院,江苏南京210029 [4]苏州大学附属第一医院江苏省血液病研究所,江苏苏州215006

出　　处：《现代肿瘤医学》2010年第3期552-554,共3页Journal of Modern Oncology

摘　　要：目的:探讨伴有复杂核型的急性早幼粒细胞白血病的临床和实验室特征。方法:应用常规细胞遗传学,间期荧光原位杂交技术(FTSH),多重荧光原位杂交技术,检测2例急性早幼粒细胞白血病。结果:常规细胞遗传学检测发现2例具有复杂核型,间期FISH证实2例均含有PML/RARA融合基因,多重FISH明确复杂核型性质。2例预后均较差。结论:联合常规细胞遗传学,间期FISH,多重FISH可以准确明确复杂核型的性质。具有复杂核型的急性早幼粒细胞白血病患者预后较差。Objective：To explore the clinical and laboratory characteristics of complex karyotypic abnormalities of acute promyelocytic leukemia. Methods： Multiplex fluorescence in situ hybridization was used in combination with conventional cytogenetics and interphase fluorescence in situ hybridization to study two cases of acute promyelocytic leukemia patients with complex karyotypic abnormalities. Results： Conventional cytogenetics detected complex chro- mosome abnormalities. All complex chromosome abnormalities were confirmed precisely by multiplex fluorescence in situ hybridization. Two patients had poor prognosis. Conclusion： Multiplex fluorescence in situ hybridization in com- bination with conventional cytogenetics may characterize the complex chrmosomal abnormalities more precisely. Acute promyelocytic leukemia patients with complex karyotype had a bad response to chemotherapy and poor prognosis.

关 键 词：急性早幼粒细胞白血病 复杂核型 多重荧光原位杂交 

分 类 号：R733.7[医药卫生—肿瘤]