下颌垂直向功能性移位后髁突软骨的形态学及组织学改建  

Morphological and histological adaptation after mandibular functional positioning only in vertical dimension

作　　者：储沨婷[1] 唐国华[1] 沈刚[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔正畸科.上海市口腔医学重点实验室,上海200011

出　　处：《上海口腔医学》2010年第1期86-90,共5页Shanghai Journal of Stomatology

基　　金：上海市科学技术委员会资助项目(08DZ2271100);上海市重点学科建设项目(S30206)~~

摘　　要：目的:通过诱发大鼠下颌骨垂直向功能性移位,阐明这一方向上的位移在髁突改建中的作用。方法:5周龄雌性SD大鼠40只,随机分为实验组和对照组,实验组大鼠佩戴上颌后牙垫,使下颌骨发生垂直向功能性移位。实验组大鼠进一步分为4组,每组5只,分别在佩戴垫后第3、6、9、12天处死。采用组织形态学测量及AB-PAS染色,定量分析髁突的形态及软骨的组织学变化。采用SPSS11.0软件包对对照组和实验组的各项指标进行统计学分析。结果:下颌垂直向功能性移位后12d,髁突高度较对照组显著增加,前斜面更倾斜;髁突后上区前成软骨细胞及成软骨细胞层厚度在实验第3～6天无明显差异,第9天开始出现显著变化,实验组较对照组显著增厚,这种变化持续到实验第12天;肥大软骨细胞层厚度在实验第3、9、12天,实验组与对照组无显著差异,在实验第6天较对照组显著减少,间充质细胞层变化不大。结论:下颌垂直向功能性移位可致髁突高度增加、前斜面更倾斜,髁突软骨厚度的增加是髁突高度增加的组织学基础,垂直向移位也是构成功能性矫治器促进下颌骨发育的重要方面。PURPOSE： To elucidate the role of mandibular vertical functional positioning in condylar adaptive remodeling. METHODS： Forty female Sprague-Dawley rats at the age of 5 weeks were randomly divided into 4 control and experimental groups. All the animals were sacrificed on day 3, 6, 9 and 12 （n=5）. Bite plates on upper posterior teeth were fitted on the experimental animals to induce functional repositioning of the mandible. Morphological and histological analysis was carried out to quantitatively analyze the amount of the adaptive changes of condylar cartilage. Independent- samples t test and One-Way ANOVA using SPSS11.0 software package were performed. RESULTS： Twelve days after mandibular vertical functional positioning the condylar height increased. Nine days after mandibular vertical functional positioning the thickness of prechondroblast layer and chondroblast layer increased significantly compared with control groups. However the thickness of hypertrophic layer decreased significantly after 6 days’ mandibular repositioning. No change was found in the thickness of mesenchymal layer during the experimental period. CONCLUSIONS： Mandibular vertical functional positioning could enhance the growth of condyle. The resulted adaptive remodeling in condylar cartilage plays an important role in the treatment mechanism of mandibular deficiency via functional appliances.

关 键 词：功能性矫治器 垫 髁突 软骨内成骨 

分 类 号：R783.5[医药卫生—口腔医学]