生活干预对肥胖青少年动脉粥样硬化危险因素的影响研究  

Influence of Life Intervention on Atherosclerosis Risk Factors in Obese Adolescents

作　　者：何延华 周叶英[2] 李淑英[2] 孙胜英[2] 刘敏[2] 

机构地区：[1]济南市历下区疾病预防控制中心,山东济南250014 [2]山东省千佛山医院,山东济南250014

出　　处：《预防医学论坛》2010年第2期115-117,共3页Preventive Medicine Tribune

摘　　要：[目的]探讨生活干预对肥胖青少年动脉粥样硬化危险因素的影响。[方法]2007年在济南市历下区选择35名肥胖中学生,进行为期8个月的生活干预,于干预前后分别检测血压、颈动脉内膜中层厚度、内皮依赖的血管舒张功能、最大的腹膜前脂肪厚度和最小的皮下脂肪厚度、血清胰岛素、高敏C反应蛋白、甘油三酯、高密度和低密度脂蛋白胆固醇,计算稳态模型胰岛素抵抗指数。[结果]干预后高敏C反应蛋白、胰岛素抵抗指数、空腹胰岛素、最大的腹膜前脂肪厚度、收缩压、甘油三酯、低密度脂蛋白降低(P<0.01或P<0.05)。[结论]适当有效的生活干预,能够改善肥胖青少年的动脉粥样硬化危险因素。[Objective]To study the influence of life intervention on atherosclerosis risk factors in obese adolescents. [Methods]The study group comprised 35 obese adolescents aged 15-17 years in lixia District Ji＇nan in 2007. The blood pressure,the intima-media thickness of carotid artery, the function of the endothelium-dependent vasodilation, the largest thickness of pre-peritoneal fat and the minimum thickness of subcutaneous fat, fasting insulin, high-sensitivity C- reactive protein,triglycerides,high density lipoprotein and low-density lipoprotein were detected before and after life intervention for 8 months,the Homestasis model of assessment of insulin resistance was calculated. [Results]The level of the high-sensitivity C-reactive protein, the Homestasis model of assessment of insulin resistance, fasting insulin, the largest thickness of pre-peritoneal fat,systolic pressure, triglycerides and low density lipoprotein were significant decreased after life intervention（P〈0.05 or P〈0.01）. [Conclusion]The effective life intervention could improve the atherosclerosis risk factors in obese adolescents.

关 键 词：肥胖 青少年 动脉粥样硬化 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]