氨基酸组成聚类、蛋白质结构型和结构型的预测  

THE CLUSTERING OF AMINO ACID COMPOSITION,THE STRUCTURAL CLASSES OF PROTEINS AND THEIR PREDICTION

作　　者：李晓琴[1] 罗辽复[1] 

机构地区：[1]内蒙古大学物理系

出　　处：《生物物理学报》1998年第4期729-736,共8页Acta Biophysica Sinica

基　　金：国家自然科学基金

摘　　要：用信息聚类方法对蛋白质的氨基酸组成进行聚类，发现存在梯级成团（大集团分解成小集团）现象，６４５个蛋白质可分成１５个小集团，每一个小集团与蛋白质二级结构含量决定的结构型有一定相关性，但与蛋白质五大结构型相关性不明显。指出了由氨基酸成分和二级结构含量预测结构型的方案中存在的问题。提出了由蛋白质二级结构序列预测蛋白质结构型的新方法。By use of information clustering of amino acid compositions we obtained the tree-like clustering of 645 proteins and studied the relation between structural classes of proteins andtheir aminoacid composition. The problems inherent in the traditional prediction method were discussed. Then a new method for predicting the structural classes of a protein basedon its secondary structure sequence was suggested. Some simple prediction rules were given.

关 键 词：氨基酸组成 信息聚类 蛋白质 二级结构 结构型 

分 类 号：Q510.1[生物学—生物化学]