氢化可的松中间体-孕甾-4-烯-17α,21-二醇-3,20-二酮-21-醋酸酯的合成  

Synthesis of intermediate of hydrocortisone of pregn-4-ene-17α,21-dihydroxy-3,20-dione-21-acetate

作　　者：何明华[1] 廖清江[2] 

机构地区：[1]广东医学院药学院药物化学教研室,东莞523808 [2]中国药科大学药物化学教研室,南京210009

出　　处：《中国新药杂志》2010年第3期233-235,共3页Chinese Journal of New Drugs

摘　　要：目的:以雄烯二酮(AD)为原料合成氢化可的松中间体。方法:从AD出发,通过醚化保护,Wittig反应,KMnO4氧化,Py.SO3氧化合成氢化可的松中间体孕甾-4-烯-17α,21-二醇-3,20-二酮-21-乙酸酯。结果:C17位引入侧链基团。结论:该方法合理,合成路线短,反应条件温和,适宜工业化生产。Objective：To synthesize the intermediate of hydrocortisone. Methods：Androstendione （AD） was primer. The intermediate of hydrocortisone, pregn-4-ene-17α,21- dihydroxy-3,20-dione-21-acetate was synthesized using the etherification protection, Wittig reaction, the KMnO4 oxidation, Py·SO3 oxidation synthesis. Results：C17-side chain was induced into group. Conclusion： The synthesis route has less synthetic steps and a mild condition. It was suitable for industral production.

关 键 词：雄烯二酮 氢化可的松中间体 孕甾4-烯-17α 21-二醇-3 20-二酮-21-乙酸酯 合成 

分 类 号：R977.11[医药卫生—药品]