康莱特注射液对肿瘤恶病质实验模型的细胞免疫功能影响  

Effect of kanglate injuction on cellular immunological function of tumor cachexia modeal

作　　者：邓松华[1] 徐振山[2] 刘爱国[3] 张宝霆[1] 

机构地区：[1]安徽医科大学病理生理学教研室,合肥320032 [2]安徽省蚌埠医学院免疫学教研室,蚌埠233000 [3]安徽省肿瘤医院外科,蚌埠233000

出　　处：《中国药理学通报》1998年第5期445-447,共3页Chinese Pharmacological Bulletin

摘　　要：目的探讨癌症恶病质时机体细胞免疫功能变化及康莱特（kanglaite，KLT）对癌症恶病质的治疗作用。方法建立T739小鼠癌症恶病质模型，观察KLT对模型鼠细胞免疫功能的作用。结果KLT可明显降低小鼠血清中肿瘤坏死因子（TNF-α）水平，并可提高NK细胞活性和促进小鼠脾淋巴细胞增殖。结论康莱特对小鼠癌症恶病质时受损的细胞免疫功能有较好的恢复作用。AIM To investigate the change of cellular immunological function during cancer cachexia and the therapeutic effect of kanglaite (KLT) for the cachexia. METHODS T739 murine model of cancer cachexia was established to observe the effect of KLT on the cellular immunological function of the mouse. RESULTS KLT markedly decreased the serum TNF-α level of the mice and increased NK cell activity as well as promoted the spleen lymphocyte proliferation of the mouse. CONCLUSIONS It is suggested that that KLT might have some effects on improving the impaired immune function of the mouse in cancer cache-cia.

关 键 词：肿瘤恶病质 药物疗法 康莱特 细胞免疫功能 

分 类 号：R730.5[医药卫生—肿瘤] R730.3[医药卫生—临床医学]