皮下埋藏麝香对BALB/c纯系小鼠恶性肿瘤生长影响的实验研究  

Impact of Subcutaneosly Embedded Musk on the Growth of Transplanted Tumor in Pure bred Rats

作　　者：孟照华[1] 单礼成[1] 曾家修[1] 张树伟 王淑珍 张荫昌 宫伟 辛燕 赵东凯 范西红[1] 王晨龙[1] 孙英刚[1] 

机构地区：[1]济南军区总医院普外科

出　　处：《中国肿瘤临床》1998年第11期834-836,共3页Chinese Journal of Clinical Oncology

摘　　要：利用纯品麝香埋藏于ＢＡＬＢ／ｃ纯系小鼠恶性肿瘤的同位和异位，并设对照组、单纯麝香无肿瘤组及正常饲养组作对照观察。结果：实验组癌瘤重量、大小，显著小于对照组（Ｐ＜０．０１），本组生存期显著高于对照组（Ｐ＜０．０１），实验组ＮＫＩＬ－２Ｒ及Ｔ－ＴＲ显著高于其它３组，说明麝香具有提高非特异性免疫功能的作用。To evaluate the effect of musk on malignant tumors,an experiment of subcutaneous embedding of musk in pure bred rats bearing tumor transplant were made. Rats were divided into 4 groups; A)experiment group in which the musk was embedded isotopically and B) heterotopically; C) control in which the musk was either embedded in the rats without tumor, or D) rats with tumor but no musk.The results showed that the weight and the size of tumor in experiment group A,B reduced markedly than those in the control group C ( P <0.01), and that the survival of rats in the treated group was significantly longer than in the control group ( P <0.01). The fact that the values of NK,IL 2R and T TR of the rats with isotopically embedding of musk were significantly higher than the other 3 groups indicates that the musk has the effect in raising the non specific immunity without inflicting toxicity on vital organs even in a large dosage (40 times of the usual dose).

关 键 词：动物模型 恶性肿瘤 麝香 抗肿瘤作用 皮下埋藏 

分 类 号：R730.53[医药卫生—肿瘤]