镍铬烤瓷冠修复患者尿镍铬水平调查研究  

Investigation on the urine excretion of nickel and chromium related to nickel-chromium alloy dental restoration

作　　者：徐碧瑶[1] 王学才[2] 宋建根[2] 王法弟[2] 夏刚[3] 吴强松[3] 王奥琳[1] 姜庆五[3] 陈波[1] 

机构地区：[1]复旦大学公共卫生学院营养与食品卫生教研室,上海200032 [2]浙江省德清县疾病预防控制中心 [3]复旦大学公共卫生学院流行病学教研室

出　　处：《中华口腔医学研究杂志（电子版）》2010年第1期26-29,共4页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：上海市公共卫生优秀青年人才培养计划项目(08GWQ003);复旦大学曦源项目(092403)

摘　　要：目的探讨佩戴镍铬烤瓷冠材料对患者尿镍铬水平的影响。方法对浙江某县45例烤瓷冠修复患者进行问卷调查,其中接触组(镍铬烤瓷冠)37例、对照组(含钛烤瓷冠)8例,对其收集尿样并测定尿中镍、铬的水平。结果两样本t检验结果显示,镍铬烤瓷冠修复患者尿镍水平(平均1.47μg/g肌酐)与对照组(平均1.55μg/g肌酐)相比差别很小,接触组尿铬水平(平均2.06μg/g肌酐)高于对照组(平均1.17μg/g肌酐),但差异均没有统计学意义。线性回归分析结果显示,在控制性别、年龄、体质指数、吸烟和饮酒等因素的影响后,所有研究对象尿镍和尿铬水平均不受佩戴烤瓷冠的类型、时间和数量的影响(P>0.1)。结论本研究结果显示,目前尚不能认为镍铬烤瓷冠材料促进镍铬经尿排泄,需进一步加大样本量进行研究。Objective To explore the effect of wearing dental nickel-chromium alloy porcelainfused-to-metal （PFM） crowns on the levels of urinary nickel and chromium. Methods Forty-five patients wearing dental PFM crowns, including 37 nickel-chrome alloy PFM crowns as the exposed group and 8 Titanium （Ti） alloy PFM crowns as the control group. Each of the participants was required to provide a urine sample for the measurement of urinary nickel and chromium and to fill a questionnaire. Results The independent-samples Student t tests showed that there was no significant differences between the levels of urinary nickel in the studied group （mean： 1.47 μg/g crea） and the control group （mean： 1.55 μg/g crea）. Although the level of urinary chromium in the study group （mean： 2.06 μg/g crea） was higher than the control group （mean： 1.17 μg/g crea）, there was no statistic significance. After adjusting the potential confounders, muhivariable linear regression analyses also showed that the wearing of PFM crowns （type, time and number） had no effects on the level of urinary nickel and chromium （P 〉 0.1）. Conclusions The conclusion that dental nickel-chrome alloy restoration can increase the excretion levels of urinary nickel and chromium cannot be drawn from the results of this study yet. This conclusion needs to be proved by larger samples in future studies.

关 键 词：镍铬烤瓷冠 尿镍 尿铬 

分 类 号：R783[医药卫生—口腔医学]