肝细胞癌患者中p53基因变化的相关因素分析  

The Analysis of Related Factors for Aberrations of p53 Gene in Hepatocellular Carcinoma

作　　者：彭晓谋[1] 彭文伟[1] 姚集鲁[1] 陈雪娟[1] 陈青[1] 顾琳[1] 

机构地区：[1]中山医科大学附属第三医院传染科,510630

出　　处：《临床肝胆病杂志》1998年第4期214-217,共4页Journal of Clinical Hepatology

摘　　要：p53基因的变化已被认为是肿瘤病因学和分子发病机制的重要线索。为了阐明HCC的主要致病因子及其在HCC发病机制中的相对意义，本研究对p53基因变化较常见的中国南部地区的70例HCC患者采用x2检验等，分析一般资料、嗜肝病毒感染和病理资料与p53基因变化的关系。结果显示，p53基因的密码子249突变与AFP阳性、HCC分化程度、HCC高度流行区、嗜肝病毒感染以及HBVDNA在癌组织中存在等因素密切相关。p53基因的LOH则与嗜肝病毒感染和癌周组织中的肝硬化程度相关。以上结果提示，HCC的主要致病因素是嗜肝病毒感染和高度流行区的某些其它因素，其中嗜肝病毒感染在HCC的病因学和分子发病机制中的意义更为重要。The aberrations of p53 gene are considered as clues for the tumor etiology and molecular carcinogenesis. In order to illustrated the main causative factor and lits significance in hepatocarcinogenesis,aberration of p53 gene was compared with clinical data,hepatoviral infection and pathological findings. The resultsshowed that codon 249 mutations were strongly related toAFP positive,differentiation, high incidence, hepatoviral infection and the existence of HBV DNA in canceroustissues. LOH of p 53 gene were strongly related to hepatoviral infection and the degree of cirrhosis in pericancerous. These findings suggested that hepatoviral infection and some factors in high incidence of HCC were the maincausative factor,Hepatoviral infection,however,might pay more important role in hepatocarcinogenesis as compared.

关 键 词：肝细胞癌 P53基因 相关因素分析 

分 类 号：R735.702[医药卫生—肿瘤]