口腔粘膜白斑、鳞癌基底膜蛋白的表达异常  

Alterations in expession of basement membrane protein in oral leukoplakia and squamous cell carcinoma

作　　者：方玲[1] 朱虹[2] 蔡家骏[2] 王颖[2] 郝鹏程[1] 

机构地区：[1]大庆油田总医院口腔科 [2]白求恩医科大学口腔医学院,长春130041

出　　处：《口腔医学纵横》1998年第4期206-209,共4页Journal of Comprehensive Stomatology

摘　　要：目的了解基底膜蛋白（层粘连蛋白、纤维连接蛋白，Ⅳ型胶原）在口腔粘膜白斑，鳞状细胞癌中的表达情况。方法采用免疫组化之SP_TM法，对20例口腔粘膜白斑，20例口腔鳞状细胞癌和10例正常口腔粘膜进行染色。结果正常口腔粘膜、单纯增生性白斑LN和Ⅳ型胶原基底膜染色密度高，呈连续线状；FN基底膜染色密度低，亦呈连续线状。LN和Ⅳ型胶原的染色密度和基底膜的连续性与白斑的异常增生程度及鳞癌的分化程度（由高分化至低分化）呈负相关。异常增生性白斑、高分化鳞状细胞癌可见FN的表达增强，而低分化鳞状细胞癌基底膜染色密度未见增高，浸润性癌基底膜破坏或缺失。结论基底膜蛋白可能作为早期诊断癌前病变的一种生物学指标。Objective To observe the expression of three basement membrane proteins in oral leukoplakia and squamouscell carcinoma. Methods By immunohistochSP _TM method, staining 20 cases oral leukoplakia, 20 cases squamous cell carci noma and 10 cases normal mucosa. Results The continuous and intense staining of basement membrane in normal oralmucosa, nondysplastic leukopakia with collagen Ⅳ and laminin antibodies, the continuous and weakly staining with fibronectin antibody. The expression of collagen Ⅳ and laminin demonstrated an inverse correlation between staining intensity and basement membrane continuity in dysplastic extent of OLK and differentiated status of tumour, whereas in dysplasticleukoplakia and squamous cell carcinoma intense expression of fibronectin was evident in the basement membrane.Conclusion Emphasized the value of basement membrane proteins as biological marker for assessing oral carcinogenesis.

关 键 词：口腔粘膜白斑 口腔粘膜肿瘤 鳞癌 基底膜蛋白 

分 类 号：R739.85[医药卫生—肿瘤] R781.5[医药卫生—临床医学]