子宫内膜癌端粒酶活性研究  

Telomerase activity in human primary endometrial carcinoma

作　　者：周春晓[1] 孙建衡[1] 金顺钱[1] 刘海玲 陆士新[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院肿瘤研究妇瘤科

出　　处：《中华肿瘤杂志》1998年第6期428-430,共3页Chinese Journal of Oncology

摘　　要：目的探索端粒酶活性与子宫内膜癌发生发展的关系。方法采用ＰＣＲ－ＴＲＡＰ方法检测３４例子宫内膜癌和６例正常子宫内膜组织的端粒酶活性。结果在３４例子宫内膜癌中，２８例端粒酶活性阳性；６例正常子宫内膜组织中，有１例端粒酶活性阳性。结论端粒酶激活与子宫内膜癌的发生发展有密切关系。Objective To investigate the possible relationship between telomerase expression and progression of endometrial carcinoma. Methods Thirty four primary endometrial carcinoma and 6 normal endometrial tissue specimens were examined by means of telomeric repeat amplification protocol (TRAP) assay for telomerase activity. Results Of 34 endometrial cancer specimens, 28 (82.4%) showed telomerase activity, whereas 1 of 6 (16.7%) benign endometrial tissues exhibited telomerase activity. Conclusion Telomerase expression might contribute to the progression of endometrial carcinoma and could be used as its tumor marker.

关 键 词：子宫肿瘤 子宫内膜癌 端粒酶 聚合酶链反应 

分 类 号：R737.33[医药卫生—肿瘤]