高温与香烟联合诱变作用的研究  

Study on Induced Mutagenesis Interaction of the High Temperature and/or Cigarette Smoke

作　　者：丰慧根[1] 孙璐[1] 李延兰[1] 杨保胜[1] 柴芳[1] 

机构地区：[1]河南省新乡医学院细胞生物学教研室

出　　处：《卫生研究》1998年第6期379-381,共3页Journal of Hygiene Research

基　　金：河南省自然科学基金

摘　　要：为探讨高温、香烟及其联合的遗传毒性和诱变作用，观察用高温或／和香烟烟雾水溶物处理的人淋巴细胞和小鼠骨髓细胞微核。结果表明在体外，高温（４０℃、４１℃、４２℃、４３℃，各温度分别处理５分钟）显著诱发人淋巴细胞微核的形成（Ｐ＜０．０１），并与温度成正比，高温与香烟联合具有明显的协同作用（Ｐ＜０．０１）。同时小鼠体内实验也表明高温与高浓度香烟（每只每天灌胃相当于１．０～２．０支香烟的烟雾水溶物，连续１０天）联合对小鼠骨髓细胞微核有显著的诱发作用和复合作用（Ｐ＜０．０１）。The study aim is to research the genotoxicity and interaction of the High temperature and/or cigarette smoke.The micronucleus of human lymphocytes and bone marrow in mice were observed following heat stress and/or watersoluble cigarette smoke substances.The results indicated that the high temperature(40℃,41℃and 42℃ for 5min,respectively)significantly induced micronuclei in human lymphocytes in vitro( P <0 01).A significant synergistic effect of the high temperature and cigarette was found.When high temperature combining with high concentration cigarette smoke(1 0～2 0 cigarette/20g/d,for 10d)was used,a significant induction and interaction( P <0 01) on micronucleus of the bone marrow were also observed.The results indicated that high temperature substanance aberrations would be enhanced when the high temperature combines with cigarette smoke.

关 键 词：高温 香烟烟雾 诱变 微核率 遗传毒性 肺肿瘤 

分 类 号：TS411[农业科学—烟草工业] R734.202[医药卫生—肿瘤]