大蒜素对乙醇引起肝损伤的拮抗作用  

Effect of Allimin on Ethanol induced Hepatotoxicity in Mice

作　　者：汪晖[1] 孔锐[1] 曾汉高[1] 

机构地区：[1]湖北医科大学药理教研室

出　　处：《卫生研究》1998年第6期415-417,共3页Journal of Hygiene Research

基　　金：湖北省自然科学基金

摘　　要：研究大蒜的有效成分大蒜素对乙醇氧化性肝损伤的影响。结果表明大蒜素（１０ｍｇ／ｋｇｉｇ，ｑｄ×１０）不仅能逆转乙醇所致血清丙氨酸转氨酶和谷胱甘肽Ｓ－转移酶活性的升高，而且能明显增加乙醇肝损伤小鼠肝脏谷胱甘肽含量、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和谷胱甘肽Ｓ－转移酶活性。对乙醇所致肝脏丙二醛含量、超氧化物歧化酶和过氧化氢酶活性的改变则无明显影响。提示大蒜素能拮抗乙醇氧化性肝损伤。To study the effect of allimin, an effective component of garlic, on ethanol induced hepatotoxicity in mice. The results showed that allimin(10mg/kg ig, qd×10)could reverse the higher activities of serum ALT and glutahione s transferase (GST) in ethanol treated mice.Furthermore, allimin could significantly enhance the content of hepatic reduced glutathione (GSH), and the activities of hepatic glutathione peroxidase(GSH Px),glutathione reductase(GSH Re) and GST in ethanol induced hepatotoxicity mice. There were no remarkable changes in the hepatic catalase (Cat) and superoxide dismutase(SOD) activities. These results suggested that allimin have the effective hepato protection on ethanol induced hepatotoxicity, which is related to its selective effect on the glutathione related enzyme system.

关 键 词：乙醇 肝损伤 大蒜素 拮抗作用 

分 类 号：R285.5[医药卫生—中药学] R575.05[医药卫生—中医学]