急性脑血管病血清超敏C-反应蛋白含量变化的临床意义  

Clinical Significance of Serum High Sensitive C-reactive Protein Level in Acute Cerebrovascular Disease

作　　者：符雪涛[1] 

机构地区：[1]江苏省扬州市第一人民医院神经内科,225000

出　　处：《实用心脑肺血管病杂志》2010年第1期1-3,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨急性脑血管病患者血清超敏C-反应蛋白(hs-CRP)含量变化的临床意义。方法选择168例急性脑血管病患者和165例健康对照组作为研究对象,检测急性期和恢复期hs-CRP含量并作比较;分析血清hs-CRP含量与神经功能缺损程度评分(NIHSS)、脑梗死病灶大小、死亡率,以及与血压、血脂、血糖之间的关系。结果急性脑血管病急性期与恢复期hs-CRP含量均高于健康对照组,差异具有显著性(P<0.01);急性脑血管病血清hs-CRP含量分别与NIHSS评分、脑梗死病灶大小、死亡率呈正相关(P<0.01);脑梗死组与脑出血组间比较差异无显著性(P>0.05);hs-CRP含量与空腹血糖、收缩压、三酰甘油、总胆固醇、低密度脂蛋白水平呈正相关(P<0.01),与高密度脂蛋白水平呈负相关(P<0.01)。结论血清hs-CRP含量变化与急性脑血管病的发生、发展及预后密切相关,并与血糖、血脂、血压等血管性危险因子相关,可作为判断患者病情及评估预后的重要指标。Objective To investigate the change in serum level of high sensitive C -reactive protein （hs -CRP） in acute cerebrovascular disease and explore its clinical significance. Methods Serum level of hs - CRY was measured in 168 patients with acute cerebrovaseular disease at two different time points ： acute and recovery period （ with an interval of 14 days）, and 165 healthy volunteers as normal eontrol. The relationship among serum level of hs - CRP, NIHSS, size of cerebral infarc tion lesions, mortality rate and risk factors for eerebrovaseular disease was analyzed. Results The hs - CRP levels in patients with aeute eerebrovaseular disease were significantly higher in both the acute and reeovery period than those in normal control group （ P 〈0. 01 ）. There were positive relation between the hs - CRP levels and the NIHSS scores, size of eerebral infarction lesions and mortality rate respectively （ P 〈 0. 01 ）. There was no significant difference of hs - CRP level between eerebrovaseular infaretion group and intraeerebral hemorrhage group （ P 〉 0. 05 ）. The levels of hs - CRP were positively correlated with the serum fasting blood glucose, systolic blood pressure, triglyeerides, total cholesterol, low - density lipoprotein cholesterol respectively （ P 〈 0. 01 ）, and which were negatively correlated with high - density lipoprotein cholesterol （ P 〈 0. 01 ）. Conclusion Serum hs - CRP level is elosely correlate with the onset, development and prognosis of aeute eerebrovascular disease. It is also correlate with the risk factors for eerebrovascular disease. And it can be regarded as an important indication for condition judgement and prognosis assessment of patients with acute eerebrovaseular disease.

关 键 词：脑梗死 脑出血 超敏C-反应蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]