5-羟色胺2A受体基因多态性与精神分裂症的相关性研究  

A study on association between gene polymorphism of serotonin 2A receptor and schizophrenia.

作　　者：陈毅昌[1,2] 陈家强[1,2] 张良诚 陈志锐[1,2] 蔡教壁 黄少娟[1,2] 陈维基 郭锦滔[1,2] 古国谋 伍新尧 

机构地区：[1]佛山市第三人民医院 [2]中山医科大学生化教研组

出　　处：《中国神经精神疾病杂志》1998年第6期336-338,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省卫生厅资助

摘　　要：目的探讨５－羟色胺２Ａ受体基因多态性与精神分裂症的相关性。方法采用Ａｍｐ－ＲＦＬＰ方法对精神分裂症患者和各对照组的５－羟色胺２Ａ受体（简称５－ＨＴ２ＡＲ）基因的相关性进行了研究。结果精神分裂症患者５－ＨＴ２ＡＲ基因Ａ２Ａ２纯合子基因型频率及等位基因Ａ２频率均高于对照组（χ２＝８．９９，８３８Ｐ均＜０．０１），对发生精神分裂症的５－ＨＴ２ＡＲ基因Ａ２Ａ２纯合子相对危险度是２３６。结论本实验结果提示５－ＨＴ２ＡＲ基因的变异与精神分裂症有密切相关性。Objective To assess the association between the gene polymorphism of the serotonin 2A receptor and schizophrenia. Methods The association between gene polymorphism of serotonin 2A receptor and schizophrenia was determined with amplification restriction fragment length polymorphism (Amp-RFLP) technique in healthy persons and 272 schizophrenia patients in Guangdong, China. Results The frequency of A2A2 homozygote was higher in the patient's group than in the healthy group ( P <0.01), and the frequency of A2 allele was also higher in the patient's group than in the healthy group ( P <0.01). The relative risk of serotonia 2A receptor A2A2 homozygote for schizophrenia was 2.36. Conclusions These results indicate that there is a positive association between the variation of serotonin 2A receptor gene and schizophrenia in Guangdong, China.

关 键 词：精神分裂症 HT2AR 基因多态性 相关性研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学]