健侧颈7神经根移位直接修复对侧臂丛神经下干的动物实验模型  

The experimental model of contralateral C7 direct transfer to the injured lower trunk via subcutaneous tunnel

作　　者：罗鹏波[1] 王涛[1] 冯俊涛[1] 刘靖波[1] 

机构地区：[1]复旦大学附属华山医院手外科,上海200040

出　　处：《中华手外科杂志》2010年第1期45-47,共3页Chinese Journal of Hand Surgery

基　　金：卫生部临床学科重点项目（2007-66）;上海市周围神经显微外科重点实验室课题（05DZ22108）

摘　　要：目的建立健侧颈7神经根移位经颈前皮下直接缝合患侧下干的实验动物模型。方法清洁级雄性SD大鼠20只，以右侧为健侧，左侧为患侧，将健侧的颈，神经根前、后股经颈前皮下隧道直接与患侧的颈8、胸1神经根缝合。通过测量健侧颈，神经根至前后股远端的最大长度与前后股的直径和、颈7神经根前后股远端跨过（或未达到）颈前中线的长度、颈8胸1神经根近端跨过（或未达到）颈前中线的长度、颈8胸。神经根的直径和与缝合口的神经通过率来综合评价建立该模型的可行性。结果健侧颈，神经根至前后股远端的最大长度平均为8．15mm，颈7神经根前后股远端未达到颈前中线的长度平均为2．74／mm，前后股的直径和平均为924．64舯，颈8胸1神经根近端跨过颈前中线的长度平均为3．88mm，颈8胸1神经根的直径和平均为1296．38μm，上述二者可在颈前皮下直接缝合。缝合口的神经通过率平均为70．53％。结论大鼠健侧颈，神经根移位经颈前皮下可直接与患侧下干缝合，术后有再生神经纤维通过。该模型有效、重复性好，为研究健侧颈，神经根经颈前皮下直接缝合对侧下干提供理想的动物模型。Objective To establish an experimental model of contralateral C7 direct transfer to the injured lower trunk via subcutaneous tunnel. Methods In 20 male Sprague-Dawley rats the right side was designated as the healthy side and the left side as the injured side. The right CO nerve root and its anterior and posterior divisions were passed through a subcutaneous tunnel and directly sutured to the left Cs and T1 nerve roots. The longest length of G7 nerve root to the distal end of its divisions, the diameter of the anterior and posterior divisions combined, the length of Co anterior and posterior division, C8 and T1 roots that passed the midline or the distance of these nerve roots to the midline, the diameter of Cs and T1 roots combined, and the percentage of nerve fibers that passed the nerve coaptation site were measured. Results The longest length of C7 root to the distal end of its divisions was 8.15 mm on average. The distal end of C7 anterior and posterior divisions did not reach the midline, with an average distance of 2.74 mm. The Cs and T1 roots passed the midline for an average length of 3.88 mm. The average diameters of Co divisions combined and C8 and T1 roots combined were924.64 tan and 1 296.38μm, respectively. There were about 70.53% nerve fibers that passed the coaptation site. Conclusion The contralateral C7 root can he directly transferred to the injured lower trunk via a subcutaneous tunnel in a rat model. This model is effective and reproducible. It is an ideal model for studying contralateral Co direct transfer to the injured lower mink via subcutaneous tunnel.

关 键 词：模型 动物 神经移位 臂丛 

分 类 号：R-332[医药卫生]