免疫吸附治疗急性炎症性脱髓鞘性多发性神经病疗效观察  

Effects of immunoadsorption therapy for acute inflammatory demyelinating polyneuropathy

作　　者：韦潋滟[1] 秦新月[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆市神经病学重点实验室,重庆400016

出　　处：《重庆医科大学学报》2010年第1期88-90,共3页Journal of Chongqing Medical University

摘　　要：目的:观察免疫吸附治疗(Immunoadsorption,IA)对急性炎症性脱髓鞘性多发性神经病(Acute inflammatory demyelinating polyneuropathy,AIDP)的治疗效果。方法:对36例AIDP患者进行回顾性分析,其中15例患者行IA治疗,21例患者行隔日小剂量血浆置换(Plasma exchange,PE)治疗,以Hughes评分及MRC(Medical research council)评分对神经功能缺损进行评定,观察治疗前后神经功能缺损情况、疗效及治疗副作用。结果:2组治疗均明显改善AIDP患者的神经功能缺损情况,且无统计学差异;治疗后1天IA组治疗整体有效率明显高于PE组,但治疗后1周及2周两组间差异无统计学意义;两组按临床分型及年龄分层后,有效率比较无统计学差异。结论:与隔日小剂量PE治疗相比,IA具有同样的疗效,是治疗AIDP较为有效的方法。Objective： To evaluate the comparative efficacy of Immunoadsorption（ IA ） versus Low dose alternate day plasma exchange（PE ） in patients with acute inflammatory demyelinating polyneuropathy（AIDP）. Methods： 36 patients with AIDP were studied retrospectively. 15 were treated with IA , and 21, with Low dose alternate day PE. The neurological deficits of both groups were evaluated by Hughes scale and Medical Research Council （MRC）-score, based on which the improvement of neurological deficits and clinical efficacy were observed. Results： Both therapies improved the neurological deficits of the patients with AIDP, and there was no significant difference between them. The whole effective rate was much higher in the IA group on the 1st day after the treatment, but no significant difference was found at 1 week and 2 weeks between the two groups,which showed no significant difference in effective rate between the two groups according to the clinical types and the age stratification study.Conclusion：Compared with low dose alternate day PE,IA therapy was found with approximately the same efficacy.Therefore, IA is recommended as an alternative plasmapheresis method.

关 键 词：急性炎症性脱髓鞘性多发性神经病 免疫吸附 血浆置换 

分 类 号：R745.4[医药卫生—神经病学与精神病学]