8494例泌尿生殖道支原体感染及药敏分析  

Analysis of 8494 patients with genitourinary tract mycoplasma infection and drug susceptibility

作　　者：陈潋 程大林[2] 王淑琴[3] 

机构地区：[1]重庆都市俪人医院检验科,重庆401147 [2]重庆医科大学附属第一医院检验科,重庆400016 [3]重庆市第三人民医院检验科,重庆400014

出　　处：《重庆医科大学学报》2010年第1期127-130,共4页Journal of Chongqing Medical University

摘　　要：目的:了解本市解脲支原体(Uu)和人型支原体(Mh)引起的泌尿生殖道感染及其药物敏感情况。方法:采用支原体培养、鉴定、药敏一体化试剂盒,对8494例疑为支原体感染患者的泌尿生殖道分泌物进行培养,并测定其对10种常用抗生素的敏感性。结果:8494例可疑病例中支原体培养阳性2735例(32.2%),其中单纯解脲支原体(Uu)感染2239例(26.4%),单纯人型支原体(Mh)感染29例(0.3%),Uu与Mh双重感染467例(5.5%)。药敏试验结果显示,Uu对美满霉素、强力霉素、克拉霉素、阿奇霉素、交沙霉素、罗红霉素敏感,敏感率分别为96.4%、95.4%、94.4%、87.1%、74.2%、73.3%,对大观霉素敏感率仅为6.5%;Mh对强力霉素、美满霉素、交沙霉素、林可霉素有较高的敏感率,敏感率分别为100%、96.6%、96.6%、86.2%,对罗红霉素、阿齐霉素、克拉霉素敏感率仅分别为0%、0%,3.4%;Uu+Mh对美满霉素、强力霉素最敏感,其次为交沙霉素,敏感率分别为92.1%、89.7%和61.2%,对罗红霉素、阿齐霉素、克拉霉素、大观霉素敏感率仅分别为3.9%、5.2%、8.6%、9.4%。结论:支原体感染是引起泌尿生殖系非淋菌炎症的主要病原体之一,其感染以Uu感染为主;对支原体感染的治疗,要根据药物敏试验结果合理选用抗生素,降低耐药菌株的产生。Objective：to investigate the status of patients with genitourinary tract infection caused by Ureaplasma urealyticum （Uu） and Mycoplasma hominis （Mh）,and its drug susceptibility and resistance in Chongqing. Methods：The genitourinary tract samples from 8 494 doubtful patients with mycoplasma infection were cultured and the susceptibility of the disease to 10 routine antibiotics was measured by mycoplasma cultivation,identification and drug susceptibility integration kit. Results：In the results of mycoplasma cultivation of 8 494 doubtful cases,2 735 cases were positive （32.2%）,and 2 239 of them were simple Uu infection （26.4%）,and 29 cases were simple Mh infection（ 0.3% ） and 467 cases were double infection（5.5% ）. The results of susceptibility test showed that the sensitivity of Uu to Minocycline, Deoxycycline, Clarithromyein, Azithromycin, Josamycin and Roxithromycin was 96.4%, 95.4%, 94.4%, 87.1%, 74.2%, and 73.3%, respectively, but to spectinomycin was 6.5%. Otherwise, the sensitivity of Mh to Deoxycycline, Minoeycline,Josamycin and Lincomycin was 100%,96.6%, 96.6%, 86.2% respectively, but to Roxithromycin, Azithromyein, Clarithromycin was 0%,0%, 3.4% respectively. The double infection was the most sensitive to Minocycline and Deoxycyeline,then to Josamycin,and the sensitivity was 92.1% ,89.7% and 61.2% ,respectively,but the sensitivity of it to Roxithromycin, Azithromycin, Clarithromycin,and Spectinomyein was 3.9%, 5.2%, 8.6%,and 9.4% respectively. Conclusion： Mycoplasma is one of the main pathogen in genitourinary tract non-gonococcus inflammation,especially Uu infection. The therapy of mycoplasma infection should depress the production of drug resistant strain by the reasonable adoption of antibiotics according to the results of susceptibility test.

关 键 词：泌尿生殖道 泌尿生殖道感染 支原体感染 药敏分析 

分 类 号：R446.1[医药卫生—诊断学]