MODELING,SIMULATION,AND OPTIMIZATION OF SURFACE ACOUSTIC WAVE DRIVEN MICROFLUIDIC BIOCHIPS  

作　　者：Harbir Antil Roland Glowinski Ronald H.W.Hoppe Christopher Linsenmann Tsorng-Whay Pan Achim Wixforth 

机构地区：[1]Department of Mathematics,University of Houston [2]Institute of Mathematics,University of Augsburg [3]Institute of Physics,University of Augsburg

出　　处：《Journal of Computational Mathematics》2010年第2期149-169,共21页计算数学（英文）

基　　金：support by the NSF under Grants No. DMS-0511611, DMS-0707602, DMS-0810156, DMS-0811153;by the German National Science Foundation DFG within the Priority Program SPP 1253

摘　　要：We will be concerned with the mathematical modeling, numerical simulation, and shape optimization of micro fluidic biochips that are used for various biomedical applications. A particular feature is that the fluid flow in the fluidic network on top of the biochips is in- duced by surface acoustic waves generated by interdigital transducers. We are thus faced with a multiphysics problem that will be modeled by coupling the equations of piezoelectricity with the compressible Navier-Stokes equations. Moreover, the fluid flow exhibits a multiscale character that will be taken care of by a homogenization approach. We will discuss and analyze the mathematical models and deal with their numerical solution by space-time discretizations featuring appropriate finite element approximations with respect to hierarchies of simplicial triangulations of the underlying computational domains. Simulation results will be given for the propagation of the surface acoustic waves on top of the piezoelectric substrate and for the induced fluid flow in the microchannels of the fluidic network. The performance of the operational behavior of the biochips can be significantly improved by shape optimization. In particular, for such purposes we present a multilevel interior point method relying on a predictor-corrector strategy with an adaptive choice of the continuation steplength along the barrier path. As a specific example, we will consider the shape optimization of pressure driven capillary barriers between microchannels and reservoirs.We will be concerned with the mathematical modeling, numerical simulation, and shape optimization of micro fluidic biochips that are used for various biomedical applications. A particular feature is that the fluid flow in the fluidic network on top of the biochips is in- duced by surface acoustic waves generated by interdigital transducers. We are thus faced with a multiphysics problem that will be modeled by coupling the equations of piezoelectricity with the compressible Navier-Stokes equations. Moreover, the fluid flow exhibits a multiscale character that will be taken care of by a homogenization approach. We will discuss and analyze the mathematical models and deal with their numerical solution by space-time discretizations featuring appropriate finite element approximations with respect to hierarchies of simplicial triangulations of the underlying computational domains. Simulation results will be given for the propagation of the surface acoustic waves on top of the piezoelectric substrate and for the induced fluid flow in the microchannels of the fluidic network. The performance of the operational behavior of the biochips can be significantly improved by shape optimization. In particular, for such purposes we present a multilevel interior point method relying on a predictor-corrector strategy with an adaptive choice of the continuation steplength along the barrier path. As a specific example, we will consider the shape optimization of pressure driven capillary barriers between microchannels and reservoirs.

关 键 词：Microfluidic biochips Mathematical modeling Numerical simulation Shape optimization MULTIPHYSICS Multiscale problems. 

分 类 号：O241.82[理学—计算数学]