槐耳颗粒联合肝动脉灌注化疗栓塞治疗晚期肝癌的临床研究  

Clinical effects of Huaier and transarterial chemoembolization (TACE) in treatment of advanced hepatocellular carcinoma

作　　者：李敬东[1] 彭勇[1] 戴毅[1] 程蕾[1] 彭祥玉[1] 陶涛[1] 严德辉[1] 雷俊阳[1] 

机构地区：[1]川北医学院附属医院普外三科,四川南充637000

出　　处：《西部医学》2010年第3期418-420,共3页Medical Journal of West China

摘　　要：目的比较槐耳颗粒联合经肝动脉灌注化疗栓塞(TACE)与单纯TACE在晚期肝癌的疗效。方法将50例难以手术切除的晚期肝癌病人随机分为研究组与对照组,每组各25例。研究组患者于TACE术后第二天开始加服槐耳颗粒,1包(20g)/次,3次/日,15盒(1盒2包)为一个疗程,共6个疗程;对照组介入后同期不用任何抗肿瘤药物。比较两组病人的瘤体变化、生存质量、甲胎蛋白水平变化。结果治疗组有效率(PR+CR)为44.0%,对照组有效率(PR+CR)为32.0%。两组患者生存质量对比有显著差异(P<0.01)。研究组和对照组术前各有20例和l9例患者血清AFP值升高。经TACE治疗后,两组相比之间无显著性差异(P>0.05),但研究组AFP下降持续的平均时间较对照组长,统计学分析有显著性差异(P<0.05)。结论对于晚期肝癌行TACE治疗后,加用槐耳颗粒能提高患者的近期疗效,改善患者的生活质量,延长晚期肝癌患者行TACE后的AFP水平下降的持续时间。Objective To observe the clinical effects of Huaier and TACE in treatment of advanced hepatocellular carcinoma （HCC）. Methods 50 patients with HCC were randomly divided into two groups, Study group（n = 25）and Control group（n=25）.After TACE,Study group was treated with Huaier（60g per day） and Control group was not. The clinical effects, life quality and level of AFP were compared between Study group and Control group. Results The rate of clinical effect（decreased size of tumor）is 44% and 32. 0%in the study group and control group, respectively. Descending time of level of AFP in study group lasted longer than that of control group （10.2w±3.6w vs 4. 8w±3.3w,P〈0.05）. Conclusions Huaier may increase clinical effect, improve quality of life and last descending time of level of AFP after TACE for patients with advanced hepatocelluar carcinoma.

关 键 词：槐耳颗粒 肝动脉灌注化疗栓塞 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]