重组人血管内皮抑素联合化疗治疗多种晚期恶性肿瘤的临床观察  

Endostar combined with chemotherapy on the multiple kinds of advanced malignancies

作　　者：庞东生[1] 宋志刚[1] 汪雪原[1] 钱洪[1] 

机构地区：[1]海军安庆医院肿瘤内科,安徽安庆246003

出　　处：《西部医学》2010年第3期430-432,共3页Medical Journal of West China

摘　　要：目的前瞻性观察抗肿瘤新药重组人血管内皮抑素注射液(YH-16,恩度)联合化疗治疗多种晚期恶性肿瘤的有效性和安全性。方法经病理组织学或细胞学检查确诊的Ⅳ期恶性肿瘤患者23例,接受恩度联合化疗的方案治疗。其中恩度15mg,加入生理盐水500m1中匀速缓慢静脉滴注,第1～14天连续给药,间歇7天重复;同时联合使用化疗药物。每21天为1个周期。按照RECIST(实体瘤疗效评价标准)标准评价近期疗效,参照Kamofsky评分(KPS)变化评价生活质量(QOL),按照NCI CTC3.O版标准评价毒性反应。用药1周期即评价毒性,2周期后评价疗效。结果全组23例患者中,有21例患者可以评价客观疗效,23例均可进行安全性评价。总共完成的周期数为50个周期,平均2.1个周期。21例可评价病例中,获得PR 2例,SD12例,PD7例,客观有效率(RR)为9.52%(2/21),疾病控制率(DCR)67.0%(14/21);而生活质量改善者7例(33.3%),稳定9例(42.8%),仅5例(23.8%)下降。G3/4级毒性主要与化疗药物有关,包括2例(8.7%)白细胞下降、1例(4.34%)血小板下降、1例(4.34%)恶心/呕吐。结论恩度与化疗药物联合使用可以改善和稳定多种晚期恶性肿瘤患者的生活质量,与部分化疗药物具有协同作用,其毒性低,安全性好。Objective To observe prospectively and systematically efficacy and safety of rhendostatin injection （YH-16,Endostar） on advanced malignancies. Methods Endostar combined with chemotherapy were administrated to 23 malignant cases of stage Ⅳ confirmed by histopathology or cytopathology. The chemotherapy agents which was not used before or not cross-resistant to pre-ehemotherapeutics agents were selected to be given simultaneously. The efficacy was evaluated after 2 courses according to RECIST（Response Evaluation Critera In Solid Tumors） criteria and quality of life （QOL）. The safety was evaluated according to NCI CTC 3.0 version criteria. Results Of the 21 evaluable eases, there were 2 cases with PR, 12 eases with SD, and 7 cases with PD. The objective response rate （RR） was 9.52% and disease control rate （DCR） was 67.0%. The quality of life （QOL） were improved on 7 cases （33.3%）, stabled on 9 cases （42.8%） , and decreased on 5cases （23.8%）. The occurrence rates of G3/4 toxicities were low, including neutropenia （2/23, 8.7% ）, thrombocytopenia （1/23, 4.34%）, nausea/vomiting （1/23, 4. 34% ）. Conclusion The QOL of patients with multiple kinds of advanced malignancies may be improved by endostar combined with the related chemotherapy.

关 键 词：重组人血管内皮抑素/恩度 晚期恶性肿瘤 化疗 抗肿瘤血管形成 

分 类 号：R730.53[医药卫生—肿瘤]