血管内皮生长因子和肝细胞生长因子在烟雾病发病机制中的作用  

Role of vascular endotheial growth factor and hepatocyte growth factor in the pathogenesis of Moyamoya disease

作　　者：尤志珺[1] 周少华[1] 席刚明[1] 

机构地区：[1]十堰市郧阳医学院附属人民医院神经内科,湖北十堰442000

出　　处：《西部医学》2010年第3期441-442,445,共3页Medical Journal of West China

摘　　要：目的探讨烟雾病患者血清血管内皮生长因子(VEGF)和肝细胞生长因子(HGF)的水平、临床意义及在烟雾病发病机制中的作用。方法采用双抗体酶联免疫吸附法(ELISA)测定20例烟雾病患者和20例健康对照血清VEGF和HGF的水平。结果烟雾病患者血清VEGF和HGF水平明显高于正常对照组,两组比较差异均具有显著性意义(P<0.01)。结论VEGF和HGF在烟雾病的发生、发展过程中有重要作用。Objective To investigate the role of vascular endotheial growth factor （VEGF） and hepatocyte growth factor （HGF） in the pathogenesis of Moyamoya disease （MMD）. Methods The serum level of VEGF and HGF in 20 patients with MMD and 20 healthy control subjects were examined by enzyme-linked immunosorbent assay （ELISA）. Results Compared with the normal control group, the level of VEGF and HGF in patients with MMD were significantly high （P〈0. 01）. Conclusions The VEGF and HGF may play a role in the occurrence and development of moyamoya disease.

关 键 词：烟雾病 血管内皮生长因子 肝细胞生长因子 

分 类 号：R739.630.4[医药卫生—肿瘤] R692[医药卫生—临床医学]