神经生长因子受体在腺样囊性癌神经侵袭中的作用  

Effect of receptors of nerve growth factor on the perineural invasion of adenoid cystic carcinoma (ACC) of salivary glands

作　　者：宋晓萌[1,2] 俞大力[3] 吴煜农[1,2] 陈洁[1,2] 

机构地区：[1]南京医科大学口腔医学研究所 [2]江苏省口腔医院口腔颌面外科,江苏南京210029 [3]泰州市职业技术学院,江苏泰州225300

出　　处：《西部医学》2010年第3期470-472,共3页Medical Journal of West China

基　　金：南京医科大学校基金面上项目(06NMUM37)

摘　　要：目的研究神经生长因子受体TrkA及p75在涎腺腺样囊性癌嗜神经性中的作用。方法采用免疫组织化学方法(S-P法)检测40例涎腺腺样囊性癌组织中TrkA及p75的表达,并比较嗜神经组与非嗜神经组间TrkA/p75染色强度相对值的差异并进行统计分析。结果在40例ACC组织中,神经侵袭组有19例,非神经侵袭组21例。Tr-kA表达阳性率90%,嗜神经组TrkA表达较非嗜神经组增强,差异有统计学意义(P<0.05)。p75阳性表达率90%,嗜神经组p75表达较非嗜神经组亦增强,差异有统计学意义(P<0.05);嗜神经组TrkA/p75染色强度相对值较非嗜神经组显著增高,差异有显著统计学意义(P<0.01)。结论TrkA与p75的表达升高与ACC的嗜神经性均有关;TrkA在腺样囊性癌神经侵袭过程中可能发挥更为重要的作用。To study the expression and the role of receptors of nerve growth factor in the perineural invasion of adenoid cystic carcinoma （ACC） of salivary glands. Methods The expression of TrkA and p75 were detected by immunohistoehemistry in adenoid cystic carcinoma tissues of different human salivary glands. Results TrkA was positive in 36 （90%） cases and p75 was positive in 36 （90%） cases. TrkA and p75 were both positive in 33 cases. 21 cases showed perineural invasion. The ratio of TrkA/p75 in perineural invasion was higher than that of non-perineural invasion （P〈 0.01）. Conclusion TrkA may play a more important role than p75 in the perineural invasion of adenoid cystic carcinoma of human salivary glands.

关 键 词：酪氨酸激酶A P75 腺样囊性癌 神经侵袭 

分 类 号：R739.87[医药卫生—肿瘤] R758.63[医药卫生—临床医学]