磁性氧化铁纳米颗粒在肿瘤靶向治疗中的应用及进展  

Application and advancement of magnetic iron-oxide nanoparticles in tumor-targeted therapy

作　　者：陈月[1] 陈宝安[1] 

机构地区：[1]东南大学临床医学院附属中大医院血液科,江苏南京210009

出　　处：《癌症》2010年第1期125-128,共4页Chinese Journal of Cancer

基　　金：国家自然科学基金项目(No.30872970);国家863项目重点工程(No.2007AA022007);高等院校博士学科专项科研基金(No.20070286042)~~

摘　　要：近年来,磁性纳米颗粒由于其独特的表面比效应、小尺寸和量子尺寸效应以及磁性特性受到人们的关注,它们在生物科学和医学中的潜在应用也在过去的数十年间得到迅速发展。其中,经过适当表面修饰的磁性氧化铁纳米颗粒应用前景最为光明,已经被广泛运用于众多的体内实验性应用研究,如磁共振成像、组织修复、免疫测定、生物液体制品的解毒、药物递送、过热疗法以及细胞分离等。本文重点综述磁性氧化铁纳米颗粒的研究现状与进展,阐述其药物递送及磁致过热效应在肿瘤靶向治疗方面的应用,以及磁性纳米铁颗粒长期发展面临的挑战及可能的发展前景。Recently,nanometer-sized magnetic particles have been intensively concerned and investigated due to their particularly large surfaceto-volume ratio,quantum-size effect,magnetic character as well as their potential application in the area of bioscience and medicine,which has dramatically increased over the past several decades.Very promising nanoparticles are magnetic iron-oxide nanoparticles with appropriate surface modification,which have been widely used experimentally for numerous in vivo applications such as magnetic resonance imaging contrast enhancement,tissue repair,immunoassay,detoxification of biological fluids,drug delivery,hyperthermia,cell separation,and so on.To focus on one of the most important and fascinating subjects in nanobiotechnology,this review described the current situation and development of magnetic iron-oxide nanoparticles and their applications in drug delivery and hyperthermia in tumor-targeted therapy.The possible perspectives and some challenges to further development of these nanoparticles were also analyzed and discussed.

关 键 词：纳米科技 磁性纳米颗粒 铁氧化物 药物递送 热疗 肿瘤靶向治疗 应用 进展 

分 类 号：R730.59[医药卫生—肿瘤]