滋肾通络方对MCAO大鼠血清(血浆)NO/ET-1含量的影响  

Influence of Nourishing Kidney and Dredging Collaterals Recipe on Content of NO/ET-1 in Plasmic of MCAO Rats

作　　者：刘慧敏[1] 王华[2] 

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院保健科,山东济南250011

出　　处：《辽宁中医药大学学报》2010年第3期22-23,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：山东省中医药管理局立项科研项目(2007-098)

摘　　要：目的:观察滋肾通络方对MCAO大鼠血清(血浆)NO/ET-1含量的影响。方法:制作MCAO大鼠模型,随机分为假手术组、模型组、中药高剂量组、中药低剂量组和西药组。灌胃20天后,大鼠腹主静脉取血,分别以化学法和放射免疫法测定血清NO、血浆ET-1值,并计算NO/ET-1比值。结果:滋肾通络方可明显升高模型大鼠血清NO含量,降低大鼠血浆ET-1含量,提高NO/ET-1的比值。结论:滋肾通络方通过改善受损内皮的功能,调节血管活性物质的分泌和释放,以调节血管紧张度、增加局部血流量,恢复血管的自稳态。Objective： To observe the influence of Nourishing Kidney and Dredging Collaterals Recipe on the content of NO/ET-1 in serum of MCAO rats. Methods： Established MCAO rats model. MCAO rats were randomly divided into sham operated group, model control group, high-dose group of Chinese Medicine, low-dose group of Chinese Medicine and western medicine group. Following 20 days＇ intragastric administration, took rats＇ blood from abdominal vena, detected the content of NO and ET-1 in serum by chemical method and Radioimmunoassay, calculate the ratio of NO/ET-1. Resuhs： Nourishing Kidney and Dredging Collaterals Recipe can increase the content of NO, and reduce the content of ET in Serum, then increase the ratio of NO/ET-1. Conclusion： Nourishing Kidney and Dredging Collaterals Recipe could regulate the vascular tone, increase local blood flow, recover the vessel homostasis by improving the function of injured endothelia and regulate the secretion and the release of vasoactive substances.

关 键 词：滋肾通络方 MCAO大鼠 NO ET-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]