环氧化酶-2和细胞周期调节蛋白在食管鳞癌中的表达  

Expressions of COX-2 and cell cycle-regulatory proteins in esophageal squamous cell carcinoma

作　　者：张云雷[1] 黄俊星[2] 宋振缃 肖蔚[3] 

机构地区：[1]南通大学医学院,226001 [2]泰州市人民医院肿瘤科 [3]泰州市人民医院病理科

出　　处：《江苏医药》2010年第3期261-265,共5页Jiangsu Medical Journal

基　　金：江苏省医学重点人才(RC2007036)

摘　　要：目的探讨环氧化酶-2（COX-2）和细胞周期调节蛋白（Ki-67、cyclin A、p27）在食管鳞癌（ESCC）中的表达及其相关性。方法随机选取ESCC根治术后的切除标本102例和28例癌旁正常鳞状上皮组织。应用免疫组化检测COX-2、Ki-67、细胞周期蛋白A（cyclin A）和p27的表达。结果COX-2、Ki-67和cyclin A在ESCC表达明显高于癌旁正常鳞状上皮组织（P〈0．01），p27在ESCC中表达明显低于癌旁正常鳞状上皮组织（P〈0．01）。COX-2的表达与肿瘤的T分期有关，T1～1、2期表达低于T3-T4期（P〈0．05）；Ki-67、cyclin A、p27的表达与细胞分化相关（P〈0．01）；COX-2与Ki-67、cyclin A表达呈正相关，与p27表达负相关。结论COX-2的表达程度可反映ESCC的肿瘤细胞浸润深度；COX-2、Ki-67和cyclinA的高表达及p27的低表达具有相同的生物学意义。Objective To investigate the expressions of COX-2 and cell cycle regulatory proteins （Ki-67, cyclin A and p27） and the correlation between COX-2 and cell cycle-regulatory proteins in esophageal squamous cell carcinoma（ESCC）. Methods The expressions of COX-2 ,Ki-67, cyclin A and p27 were examined by immunohistochemistry in 102 surgically obtained ESCC specimens （group ESCC） and in 28 specimens of tumor-adjacent normal squamous epithelium as the controls （group C）. Results The expressions of COX-2, Ki-67 and cyclin A were higher, but the p27 expression was lower in group ESCC than those in group C （P〈 0. 01 ）. In group ESCC, COX-2 expression was lower in staging T1-T2 than that in T3-T4 （P〈0.05）. The expressions of Ki-67, cyclin A and p27 were correlated to tumor differentiation （P〈0. 01）. The COX-2 expression was positively correlated to Ki-67, cyclin A and negatively correlated to p27 expression in ESCC. Conclusion COX-2 expression can reflect the invasion of ESCC cells. The high expression of COX-2, Ki-67, cyclin A and lower expression of p27 have a similar biological significance.

关 键 词：食管肿瘤 环氧化酶-2 KI-67 P27 周期蛋白A 

分 类 号：R735[医药卫生—肿瘤]