颈交感神经干离断减轻鼠急性胃黏膜损伤  

Transection of cervical sympathetic trunk alleviates acute gastric mucosal lesions in rats

作　　者：赵广翊[1] 田悦[1] 孟凌新[1] 

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳110004

出　　处：《江苏医药》2010年第3期297-298,共2页Jiangsu Medical Journal

基　　金：辽宁省教育厅高校科研项目基金(20061022)

摘　　要：目的探讨颈交感神经干离断(TCST)对大鼠急性胃黏膜损伤的保护作用。方法30只雄性SD大鼠,随机分为假手术(A)组、假手术后浸水(B)组和TCST后浸水(C)组,每组10只。B、C组大鼠垂直浸水至剑突水平6 h,测各组大鼠胃黏膜血流量(GMBF),评定黏膜溃疡指数(UI)。采用放免法检测胃黏膜组织降钙素基因相关肽(CGRP)含量,硝酸还原酶法测定胃黏膜组织中一氧化氮合酶(NOS)含量。结果B、C组胃黏膜见出血性溃疡,B组损伤较重。B组GMBF、CGRP降低及UI、NOS明显高于C组(P<0.05或P<0.01)。结论TCST对大鼠急性胃黏膜损伤有保护作用,其机制可能与调节胃黏膜组织CGRP及NOS含量有关。Objective To investigate the protective effect of transections of the cervical sympathetic trunk （TCST） on the gastric mucosal lesions in rats. Methods Thirty male SD rats were randomly allocated into sham operation group（A）, sham operation and water immersion restrain for 6 h group（B） and TCST followed by water immersion restrain for 6 h group（C）. Gastric mucosal blood flow（GMBF） was measured and gastric mucosal ulcer index （UI） was evaluated. The levels of calcitonin gene-related peptide（CGRP） and nitric oxide synthase（NOS） in gastric mucosa were determined. Results There was mucosa bleeding ulcer in groups of B and C,and the degree of injury in group B was more serious than that in group C （P〈0. 01）. GMBF and CGRP were lower in group B than those in group C （P〈0. 05 or P〈0. 01）. Conclusion TCST has a protective effect on the mucosal lesions by regulating the levels of CGRP and NOS in gastric mucosa.

关 键 词：交感神经切除术 一氧化氮合酶 降钙素基因相关肽 

分 类 号：R574[医药卫生—消化系统]